Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
Specificity
Natural and recombinant Human Xanthine dehydrogenase/oxidase
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074
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11.
"Human milk xanthine dehydrogenase is incompletely converted to the oxidase form in the absence of proteolysis. A structural explanation." Pearson A.R., Godber B.L.J., Eisenthal R., Taylor G.L., Harrison R. Submitted (2009-02) to the PDB data bank
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.59 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR CENTERS;TISSUE SPECIFICITY;ENZYME REGULATION;DISULFIDE BONDS
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Reviews of ELISA Kit for Human Xanthine dehydrogenase/oxidase