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Home / Assay Kits / ELISA Kits

ELISA Kit for Human WW domain-containing oxidoreductase

SKU : BHE13812050

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2982h
Alternative Names	Fragile site FRA16D oxidoreductase ; Short chain dehydrogenase/reductase family 41C member 1 ; FOR ; SDR41C1 ; WOX1
Categories	Elisa
Function	Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Specificity	Natural and recombinant Human WW domain-containing oxidoreductase
Subcellular Location	Cytoplasm Nucleus Mitochondrion Golgi apparatus Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus.
Detection Range	0.312-20ng/mL
Entryname	WWOX_HUMAN
Method Type	Sandwich
Platform	PF00106
Protein Name	WW domain-containing oxidoreductase
Sensitivity	0.156ng/mL
Sequence	50: MAALRYAGLD ; DTDSEDELPP ; GWEERTTKDG ; WVYYANHTEE ; KTQWEHPKTG ; 100: KRKRVAGDLP ; YGWEQETDEN ; GQVFFVDHIN ; KRTTYLDPRL ; AFTVDDNPTK ; 150: PTTRQRYDGS ; TTAMEILQGR ; DFTGKVVVVT ; GANSGIGFET ; AKSFALHGAH ; 200: VILACRNMAR ; ASEAVSRILE ; EWHKAKVEAM ; TLDLALLRSV ; QHFAEAFKAK ; 250: NVPLHVLVCN ; AATFALPWSL ; TKDGLETTFQ ; VNHLGHFYLV ; QLLQDVLCRS ; 300: APARVIVVSS ; ESHRFTDIND ; SLGKLDFSRL ; SPTKNDYWAM ; LAYNRSKLCN ; 350: ILFSNELHRR ; LSPRGVTSNA ; VHPGNMMYSN ; IHRSWWVYTL ; LFTLARPFTK ; 400: SMQQGAATTV ; YCAAVPELEG ; LGGMYFNNCC ; RCMPSPEAQS ; EETARTLWAL ; 414: SERLIQERLG ; SQSG
Sequence Length	414
String	Q9NZC7
Sub Unit	Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with COTE1/C1orf2 and SCOTIN. Interacts with TNK2.

Uniprot	Q9NZC7
Gene Name	WWOX
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:51741
Unigene	Hs.461453

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812050	E2982h	96T	$736		Add to Cart

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