May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.
Specificity
Natural and recombinant Human Wilms tumor protein 1-interacting protein
Subcellular Location
Cell junction adherens junction Nucleus Translocates from cell-cell junctions to the nucleus in puromycin aminonucleoside-treated podocytes.