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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Von Hippel-Lindau disease tumor suppressor

SKU : BHE13811922

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1894h
Alternative Names	Protein G7 ; pVHL
Categories	Elisa
Function	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
Specificity	Natural and recombinant Human Von Hippel-Lindau disease tumor suppressor
Subcellular Location	Isoform 3 Cytoplasm Nucleus Equally distributed between the nucleus and the cytoplasm but not membrane-associated.
Detection Range	0.156-10ng/mL
Entryname	VHL_HUMAN
Method Type	Sandwich
Platform	PF01847
Protein Name	Von Hippel-Lindau disease tumor suppressor
Sensitivity	0.078ng/mL
Sequence	50: MPRRAENWDE ; AEVGAEEAGV ; EEYGPEEDGG ; EESGAEESGP ; EESGPEELGA ; 100: EEEMEAGRPR ; PVLRSVNSRE ; PSQVIFCNRS ; PRVVLPVWLN ; FDGEPQPYPT ; 150: LPPGTGRRIH ; SYRGHLWLFR ; DAGTHDGLLV ; NQTELFVPSL ; NVDGQPIFAN ; 200: ITLPVYTLKE ; RCLQVVRSLV ; KPENYRRLDI ; VRSLYEDLED ; HPNVQKDLER ; 213: LTQERIAHQR ; MGD
Sequence Length	213
String	P40337
Sub Unit	Component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins. Interacts with CUL2; this interaction is dependent on the integrity of the trimeric VBC complex. Interacts (via the beta domain) with HIF1A (via the NTAD domain); this interaction mediates degradation of HIF1A in normoxia and, in hypoxia, prevents ubiqitination and degradation of HIF1A by mediating hypoxia-induced translocation to the nucleus, a process which requires a hypoxia-dependent regulatory signal. Interacts with RNF139 and USP33. Interacts with PHF17.

Uniprot	P40337
Gene Name	VHL
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7428
Unigene	Hs.517792

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811922	E1894h	96T	$736		Add to Cart

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