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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Ubiquitin-protein ligase E3A

SKU : BHE13812018

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9055h
Alternative Names	E6AP ubiquitin-protein ligase ; HECT-type ubiquitin transferase E3A ; Human papillomavirus E6-associated protein ; Oncogenic protein-associated protein E6-AP ; Renal carcinoma antigen NY-REN-54 ; E6AP ; EPVE6AP ; HPVE6A
Categories	Elisa
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.
Specificity	Natural and recombinant Human Ubiquitin-protein ligase E3A
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	UBE3A_HUMAN
Method Type	Sandwich
Platform	PF00632
Protein Name	Ubiquitin-protein ligase E3A
Sensitivity	0.1ng/mL
Sequence	50: MEKLHQCYWK ; SGEPQSDDIE ; ASRMKRAAAK ; HLIERYYHQL ; TEGCGNEACT ; 100: NEFCASCPTF ; LRMDNNAAAI ; KALELYKINA ; KLCDPHPSKK ; GASSAYLENS ; 150: KGAPNNSCSE ; IKMNKKGARI ; DFKDVTYLTE ; EKVYEILELC ; REREDYSPLI ; 200: RVIGRVFSSA ; EALVQSFRKV ; KQHTKEELKS ; LQAKDEDKDE ; DEKEKAACSA ; 250: AAMEEDSEAS ; SSRIGDSSQG ; DNNLQKLGPD ; DVSVDIDAIR ; RVYTRLLSNE ; 300: KIETAFLNAL ; VYLSPNVECD ; LTYHNVYSRD ; PNYLNLFIIV ; MENRNLHSPE ; 350: YLEMALPLFC ; KAMSKLPLAA ; QGKLIRLWSK ; YNADQIRRMM ; ETFQQLITYK ; 400: VISNEFNSRN ; LVNDDDAIVA ; ASKCLKMVYY ; ANVVGGEVDT ; NHNEEDDEEP ; 450: IPESSELTLQ ; ELLGEERRNK ; KGPRVDPLET ; ELGVKTLDCR ; KPLIPFEEFI ; 500: NEPLNEVLEM ; DKDYTFFKVE ; TENKFSFMTC ; PFILNAVTKN ; LGLYYDNRIR ; 550: MYSERRITVL ; YSLVQGQQLN ; PYLRLKVRRD ; HIIDDALVRL ; EMIAMENPAD ; 600: LKKQLYVEFE ; GEQGVDEGGV ; SKEFFQLVVE ; EIFNPDIGMF ; TYDESTKLFW ; 650: FNPSSFETEG ; QFTLIGIVLG ; LAIYNNCILD ; VHFPMVVYRK ; LMGKKGTFRD ; 700: LGDSHPVLYQ ; SLKDLLEYEG ; NVEDDMMITF ; QISQTDLFGN ; PMMYDLKENG ; 750: DKIPITNENR ; KEFVNLYSDY ; ILNKSVEKQF ; KAFRRGFHMV ; TNESPLKYLF ; 800: RPEEIELLIC ; GSRNLDFQAL ; EETTEYDGGY ; TRDSVLIREF ; WEIVHSFTDE ; 850: QKRLFLQFTT ; GTDRAPVGGL ; GKLKMIIAKN ; GPDTERLPTS ; HTCFNVLLLP ; 875: EYSSKEKLKE ; RLLKAITYAK ; GFGML
Sequence Length	875
String	Q05086
Sub Unit	Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with HCV core protein and targets it to degradation. Interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53/TP53 tumor-suppressor protein for ubiquitin-mediated proteolysis. Interacts with BPY2.

Uniprot	Q05086
Gene Name	UBE3A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7337
Unigene	Hs.598862

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812018	E9055h	96T	$736		Add to Cart

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