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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Tyrosine-protein phosphatase non-receptor type substrate 1

SKU : BHE13810402

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9001h
Alternative Names	Brain Ig-like molecule with tyrosine-based activation motifs ; Bit ; CD172 antigen-like family member A ; Inhibitory receptor SHPS-1 ; Macrophage fusion receptor ; MyD-1 antigen ; Signal-regulatory protein alpha-1 ; Sirp-alpha-1 ; Signal-regulatory protein alpha-2 ; Sirp-alpha-2 ; Signal-regulatory protein alpha-3 ; Sirp-alpha-3 ; p84 ; CD172a ; BIT ; MFR ; MYD1 ; PTPNS1 ; SHPS1 ; SIRP
Categories	Elisa
Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Specificity	Natural and recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1
Subcellular Location	Membrane Single-pass type I membrane protein
Entryname	SHPS1_HUMAN
Platform	PF07654
Protein Name	Tyrosine-protein phosphatase non-receptor type substrate 1
Sequence	50: MEPAGPAPGR ; LGPLLCLLLA ; ASCAWSGVAG ; EEELQVIQPD ; KSVLVAAGET ; 100: ATLRCTATSL ; IPVGPIQWFR ; GAGPGRELIY ; NQKEGHFPRV ; TTVSDLTKRN ; 150: NMDFSIRIGN ; ITPADAGTYY ; CVKFRKGSPD ; DVEFKSGAGT ; ELSVRAKPSA ; 200: PVVSGPAARA ; TPQHTVSFTC ; ESHGFSPRDI ; TLKWFKNGNE ; LSDFQTNVDP ; 250: VGESVSYSIH ; STAKVVLTRE ; DVHSQVICEV ; AHVTLQGDPL ; RGTANLSETI ; 300: RVPPTLEVTQ ; QPVRAENQVN ; VTCQVRKFYP ; QRLQLTWLEN ; GNVSRTETAS ; 350: TVTENKDGTY ; NWMSWLLVNV ; SAHRDDVKLT ; CQVEHDGQPA ; VSKSHDLKVS ; 400: AHPKEQGSNT ; AAENTGSNER ; NIYIVVGVVC ; TLLVALLMAA ; LYLVRIRQKK ; 450: AQGSTSSTRL ; HEPEKNAREI ; TQDTNDITYA ; DLNLPKGKKP ; APQAAEPNNH ; 500: TEYASIQTSP ; QPASEDTLTY ; ADLDMVHLNR ; TPKQPAPKPE ; PSFSEYASVQ ; 504: VPRK
Sequence Length	504
String	P78324
Sub Unit	Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

Uniprot	P78324
Gene Name	SIRPA
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:140885
Unigene	Hs.581021

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810402	E9001h	96T	$736		Add to Cart

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