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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 11A

SKU : BHE13810519

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2057h
Alternative Names	Osteoclast differentiation factor receptor ; ODFR ; Receptor activator of NF-KB ; CD265 ; RANK
Categories	Elisa
Function	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Specificity	Natural and recombinant Human Tumor necrosis factor receptor superfamily member 11A
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	0.156-10ng/mL
Entryname	TNR11_HUMAN
Method Type	Sandwich
Platform	PF00020
Protein Name	Tumor necrosis factor receptor superfamily member 11A
Sensitivity	0.067ng/mL
Sequence	50: MAPRARRRRP ; LFALLLLCAL ; LARLQVALQI ; APPCTSEKHY ; EHLGRCCNKC ; 100: EPGKYMSSKC ; TTTSDSVCLP ; CGPDEYLDSW ; NEEDKCLLHK ; VCDTGKALVA ; 150: VVAGNSTTPR ; RCACTAGYHW ; SQDCECCRRN ; TECAPGLGAQ ; HPLQLNKDTV ; 200: CKPCLAGYFS ; DAFSSTDKCR ; PWTNCTFLGK ; RVEHHGTEKS ; DAVCSSSLPA ; 250: RKPPNEPHVY ; LPGLIILLLF ; ASVALVAAII ; FGVCYRKKGK ; ALTANLWHWI ; 300: NEACGRLSGD ; KESSGDSCVS ; THTANFGQQG ; ACEGVLLLTL ; EEKTFPEDMC ; 350: YPDQGGVCQG ; TCVGGGPYAQ ; GEDARMLSLV ; SKTEIEEDSF ; RQMPTEDEYM ; 400: DRPSQPTDQL ; LFLTEPGSKS ; TPPFSEPLEV ; GENDSLSQCF ; TGTQSTVGSE ; 450: SCNCTEPLCR ; TDWTPMSSEN ; YLQKEVDSGH ; CPHWAASPSP ; NWADVCTGCR ; 500: NPPGEDCEPL ; VGSPKRGPLP ; QCAYGMGLPP ; EEEASRTEAR ; DQPEDGADGR ; 550: LPSSARAGAG ; SGSSPGGQSP ; ASGNVTGNSN ; STFISSGQVM ; NFKGDIIVVY ; 600: VSQTSQEGAA ; AAAEPMGRPV ; QEETLARRDS ; FAGNGPRFPD ; PCGGPEGLRE ; 616: PEKASRPVQE ; QGGAKA
Sequence Length	616
String	Q9Y6Q6
Sub Unit	Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2.

Uniprot	Q9Y6Q6
Gene Name	TNFRSF11A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8792
Unigene	Hs.204044

Reference	1. "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function." Anderson D.M., Maraskovsky E., Billingsley W.L., Dougall W.C., Tometsko M.E., Roux E.R., Teepe M.C., DuBose R.F., Cosman D., Galibert L. Nature390:175-179(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) tissue: Dendritic cell. 2. "Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-kappaB." Sirinian C., Papanastasiou A.D., Zarkadis I.K., Kalofonos H.P. Gene525:124-129(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RANK-E5A);SUBCELLULAR LOCATION (ISOFORMS 1 AND RANK-E5A);ALTERNATIVE SPLICING tissue: Blood. 3. "Alternative splicing generates multiple human TNFRSF11A (RANK) isoforms." Papanastasiou A.D., Sirinian C., Kalofonos H.P. Submitted (2012-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);NUCLEOTIDE SEQUENCE [MRNA] OF 159-523 (ISOFORM 5);ALTERNATIVE SPLICING tissue: Blood. 4. "Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (2005-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) tissue: Brain. 5. "RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis." Nakagawa N., Kinosaki M., Yamaguchi K., Shima N., Yasuda H., Yano K., Morinaga T., Higashio K. Biochem. Biophys. Res. Commun.253:395-400(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 6. "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor." Wong B.R., Josien R., Lee S.Y., Vologodskaia M., Steinman R.M., Choi Y. J. Biol. Chem.273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF1; TRAF2; TRAF3; TRAF5 AND TRAF6 7. "The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis." Wada T., Nakashima T., Oliveira-dos-Santos A.J., Gasser J., Hara H., Schett G., Penninger J.M. Nat. Med.11:394-399(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAB2 8. "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 9. "Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis." Hughes A.E., Ralston S.H., Marken J., Bell C., MacPherson H., Wallace R.G.H., van Hul W., Whyte M.P., Nakatsuka K., Hovy L., Anderson D.M. Nat. Genet.24:45-48(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FEO LEU-LEU-CYS-ALA-LEU-LEU-21 INS;VARIANT PDB2 ALA-LEU-LEU-LEU-LEU-CYS-ALA-LEU-LEU-21 INS;VARIANT VAL-192 10. "Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations." Guerrini M.M., Sobacchi C., Cassani B., Abinun M., Kilic S.S., Pangrazio A., Moratto D., Mazzolari E., Clayton-Smith J., Orchard P., Coxon F.P., Helfrich M.H., Crockett J.C., Mellis D., Vellodi A., Tezcan I., Notarangelo L.D., Rogers M.J., Vezzoni P., Villa A., Frattini A.more... Am. J. Hum. Genet.83:64-76(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OPTB7 ARG-53; CYS-129; GLY-170; ARG-175 AND SER-244

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