Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
Specificity
Natural and recombinant Human Tumor necrosis factor ligand superfamily member 12
Subcellular Location
Tumor necrosis factor ligand superfamily member 12, secreted form Secreted