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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Transcriptional coactivator YAP1

SKU : BHE13811777

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15210h
Alternative Names	Protein yorkie homolog ; Yes-associated protein YAP65 homolog ; YAP65
Categories	Elisa
Function	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Specificity	Natural and recombinant Human Transcriptional coactivator YAP1
Subcellular Location	Cytoplasm Nucleus Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density.
Detection Range	0.156-10ng/mL
Entryname	YAP1_HUMAN
Method Type	Sandwich
Platform	PF00397
Protein Name	Transcriptional coactivator YAP1
Sensitivity	0.054ng/mL
Sequence	50: MDPGQQPPPQ ; PAPQGQGQPP ; SQPPQGQGPP ; SGPGQPAPAA ; TQAAPQAPPA ; 100: GHQIVHVRGD ; SETDLEALFN ; AVMNPKTANV ; PQTVPMRLRK ; LPDSFFKPPE ; 150: PKSHSRQAST ; DAGTAGALTP ; QHVRAHSSPA ; SLQLGAVSPG ; TLTPTGVVSG ; 200: PAATPTAQHL ; RQSSFEIPDD ; VPLPAGWEMA ; KTSSGQRYFL ; NHIDQTTTWQ ; 250: DPRKAMLSQM ; NVTAPTSPPV ; QQNMMNSASG ; PLPDGWEQAM ; TQDGEIYYIN ; 300: HKNKTTSWLD ; PRLDPRFAMN ; QRISQSAPVK ; QPPPLAPQSP ; QGGVMGGSNS ; 350: NQQQQMRLQQ ; LQMEKERLRL ; KQQELLRQAM ; RNINPSTANS ; PKCQELALRS ; 400: QLPTLEQDGG ; TQNPVSSPGM ; SQELRTMTTN ; SSDPFLNSGT ; YHSRDESTDS ; 450: GLSMSSYSVP ; RTPDDFLNSV ; DEMDTGDTIN ; QSTLPSQQNR ; FPDYLEAIPG ; 500: TNVDLGTLEG ; DGMNIEGEEL ; MPSLQEALSS ; DILNDMESVL ; AATKLDKESF ; 504: LTWL
Sequence Length	504
String	P46937
Sub Unit	Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Interacts with TP73. Interacts with RUNX1.

Uniprot	P46937
Gene Name	YAP1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:10413
Unigene	Hs.503692

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811777	E15210h	96T	$736		Add to Cart

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