DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
Specificity
Natural and recombinant Human Transcription termination factor 2
Subcellular Location
Cytoplasm Nucleus Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.