Class B basic helix-loop-helix protein 19 ; bHLHb19 ; Immunoglobulin transcription factor 2 ; ITF-2 ; SL3-3 enhancer factor 2 ; SEF-2 ; BHLHB19 ; ITF2 ; SEF2
Categories
Elisa
Function
Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Specificity
Natural and recombinant Human Transcription factor 4
Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2.