Toll/interleukin-1 receptor-like protein ; TIL ; CD281 ; KIAA0012
Categories
Elisa
Function
Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Specificity
Natural and recombinant Human Toll-like receptor 1
Subcellular Location
Cell membrane Single-pass type I membrane protein Cytoplasmic vesicle phagosome membrane Single-pass type I membrane protein
Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.