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ELISA Kit for Human Tissue-type plasminogen activator

SKU : BHE13811181

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0525h
Categories	Elisa
Function	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration.
Specificity	Natural and recombinant Human Tissue-type plasminogen activator
Subcellular Location	Secreted extracellular space
Detection Range	0.156-10ng/mL
Entryname	TPA_HUMAN
Method Type	Sandwich
Platform	PF00008
Protein Name	Tissue-type plasminogen activator
Sensitivity	0.056ng/mL
Sequence	50: MDAMKRGLCC ; VLLLCGAVFV ; SPSQEIHARF ; RRGARSYQVI ; CRDEKTQMIY ; 100: QQHQSWLRPV ; LRSNRVEYCW ; CNSGRAQCHS ; VPVKSCSEPR ; CFNGGTCQQA ; 150: LYFSDFVCQC ; PEGFAGKCCE ; IDTRATCYED ; QGISYRGTWS ; TAESGAECTN ; 200: WNSSALAQKP ; YSGRRPDAIR ; LGLGNHNYCR ; NPDRDSKPWC ; YVFKAGKYSS ; 250: EFCSTPACSE ; GNSDCYFGNG ; SAYRGTHSLT ; ESGASCLPWN ; SMILIGKVYT ; 300: AQNPSAQALG ; LGKHNYCRNP ; DGDAKPWCHV ; LKNRRLTWEY ; CDVPSCSTCG ; 350: LRQYSQPQFR ; IKGGLFADIA ; SHPWQAAIFA ; KHRRSPGERF ; LCGGILISSC ; 400: WILSAAHCFQ ; ERFPPHHLTV ; ILGRTYRVVP ; GEEEQKFEVE ; KYIVHKEFDD ; 450: DTYDNDIALL ; QLKSDSSRCA ; QESSVVRTVC ; LPPADLQLPD ; WTECELSGYG ; 500: KHEALSPFYS ; ERLKEAHVRL ; YPSSRCTSQH ; LLNRTVTDNM ; LCAGDTRSGG ; 550: PQANLHDACQ ; GDSGGPLVCL ; NDGRMTLVGI ; ISWGLGCGQK ; DVPGVYTKVT ; 562: NYLDWIRDNM ; RP
Sequence Length	562
String	P00750
Sub Unit	Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. Binds LRP1B; binding is followed by internalization and degradation.

Uniprot	P00750
Gene Name	PLAT
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5327
Unigene	Hs.491582

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811181	E0525h	96T	$736		Add to Cart

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