Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 ; NF-kappa-B-activating protein 1 ; TAK1-binding protein 3 ; TAB-3 ; TGF-beta-activated kinase 1-binding protein 3 ; MAP3K7IP3
Categories
Elisa
Function
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Specificity
Natural and recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1.