Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
Specificity
Natural and recombinant Human Talin-1
Subcellular Location
Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Colocalizes with LAYN at the membrane ruffles.