Super protein ; SUP ; Synaptosomal-associated 25 kDa protein ; SNAP
Categories
Elisa
Function
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
Specificity
Natural and recombinant Human Synaptosomal-associated protein 25
Subcellular Location
Cytoplasm perinuclear region Cell membrane Lipid-anchor Cell junction synapse synaptosome Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region.
Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with CENPF, TRIM9, RIMS1, SNAPIN, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1.