Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.
Specificity
Natural and recombinant Human Synaptopodin
Subcellular Location
Cytoplasm cytoskeleton Cell junction tight junction Perikaryon Cell projection dendritic spine Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Asssociated with dendritic spines of a subset of synapses.