This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Specificity
Natural and recombinant Human Sodium/potassium-transporting ATPase subunit alpha-1
Subcellular Location
Cell membrane Multi-pass membrane protein Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Interacts with SIK1 (By similarity). Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1.