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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Slit homolog 2 protein

SKU : BHE13810178

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0672h
Alternative Names	SLIL3
Categories	Elisa
Function	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
Specificity	Natural and recombinant Human Slit homolog 2 protein
Subcellular Location	Secreted The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
Detection Range	78-5000pg/mL
Entryname	SLIT2_HUMAN
Method Type	Sandwich
Platform	PF00008
Protein Name	Slit homolog 2 protein
Sensitivity	39.9 pg/mL
Sequence	50: MRGVGWQMLS ; LSLGLVLAIL ; NKVAPQACPA ; QCSCSGSTVD ; CHGLALRSVP ; 100: RNIPRNTERL ; DLNGNNITRI ; TKTDFAGLRH ; LRVLQLMENK ; ISTIERGAFQ ; 150: DLKELERLRL ; NRNHLQLFPE ; LLFLGTAKLY ; RLDLSENQIQ ; AIPRKAFRGA ; 200: VDIKNLQLDY ; NQISCIEDGA ; FRALRDLEVL ; TLNNNNITRL ; SVASFNHMPK ; 250: LRTFRLHSNN ; LYCDCHLAWL ; SDWLRQRPRV ; GLYTQCMGPS ; HLRGHNVAEV ; 300: QKREFVCSGH ; QSFMAPSCSV ; LHCPAACTCS ; NNIVDCRGKG ; LTEIPTNLPE ; 350: TITEIRLEQN ; TIKVIPPGAF ; SPYKKLRRID ; LSNNQISELA ; PDAFQGLRSL ; 400: NSLVLYGNKI ; TELPKSLFEG ; LFSLQLLLLN ; ANKINCLRVD ; AFQDLHNLNL ; 450: LSLYDNKLQT ; IAKGTFSPLR ; AIQTMHLAQN ; PFICDCHLKW ; LADYLHTNPI ; 500: ETSGARCTSP ; RRLANKRIGQ ; IKSKKFRCSA ; KEQYFIPGTE ; DYRSKLSGDC ; 550: FADLACPEKC ; RCEGTTVDCS ; NQKLNKIPEH ; IPQYTAELRL ; NNNEFTVLEA ; 600: TGIFKKLPQL ; RKINFSNNKI ; TDIEEGAFEG ; ASGVNEILLT ; SNRLENVQHK ; 650: MFKGLESLKT ; LMLRSNRITC ; VGNDSFIGLS ; SVRLLSLYDN ; QITTVAPGAF ; 700: DTLHSLSTLN ; LLANPFNCNC ; YLAWLGEWLR ; KKRIVTGNPR ; CQKPYFLKEI ; 750: PIQDVAIQDF ; TCDDGNDDNS ; CSPLSRCPTE ; CTCLDTVVRC ; SNKGLKVLPK ; 800: GIPRDVTELY ; LDGNQFTLVP ; KELSNYKHLT ; LIDLSNNRIS ; TLSNQSFSNM ; 850: TQLLTLILSY ; NRLRCIPPRT ; FDGLKSLRLL ; SLHGNDISVV ; PEGAFNDLSA ; 900: LSHLAIGANP ; LYCDCNMQWL ; SDWVKSEYKE ; PGIARCAGPG ; EMADKLLLTT ; 950: PSKKFTCQGP ; VDVNILAKCN ; PCLSNPCKND ; GTCNSDPVDF ; YRCTCPYGFK ; 1000: GQDCDVPIHA ; CISNPCKHGG ; TCHLKEGEED ; GFWCICADGF ; EGENCEVNVD ; 1050: DCEDNDCENN ; STCVDGINNY ; TCLCPPEYTG ; ELCEEKLDFC ; AQDLNPCQHD ; 1100: SKCILTPKGF ; KCDCTPGYVG ; EHCDIDFDDC ; QDNKCKNGAH ; CTDAVNGYTC ; 1150: ICPEGYSGLF ; CEFSPPMVLP ; RTSPCDNFDC ; QNGAQCIVRI ; NEPICQCLPG ; 1200: YQGEKCEKLV ; SVNFINKESY ; LQIPSAKVRP ; QTNITLQIAT ; DEDSGILLYK ; 1250: GDKDHIAVEL ; YRGRVRASYD ; TGSHPASAIY ; SVETINDGNF ; HIVELLALDQ ; 1300: SLSLSVDGGN ; PKIITNLSKQ ; STLNFDSPLY ; VGGMPGKSNV ; ASLRQAPGQN ; 1350: GTSFHGCIRN ; LYINSELQDF ; QKVPMQTGIL ; PGCEPCHKKV ; CAHGTCQPSS ; 1400: QAGFTCECQE ; GWMGPLCDQR ; TNDPCLGNKC ; VHGTCLPINA ; FSYSCKCLEG ; 1450: HGGVLCDEEE ; DLFNPCQAIK ; CKHGKCRLSG ; LGQPYCECSS ; GYTGDSCDRE ; 1500: ISCRGERIRD ; YYQKQQGYAA ; CQTTKKVSRL ; ECRGGCAGGQ ; CCGPLRSKRR ; 1529: KYSFECTDGS ; SFVDEVEKVV ; KCGCTRCVS
Sequence Length	1529
String	O94813
Sub Unit	Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity.

Uniprot	O94813
Gene Name	SLIT2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:9353
Unigene	Hs.29802

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BHE13810178	E0672h	96T	$736		Add to Cart

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