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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase SIK1

SKU : BHE13810005

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14381h
Alternative Names	Salt-inducible kinase 1 ; SIK-1 ; Serine/threonine-protein kinase SNF1-like kinase 1 ; Serine/threonine-protein kinase SNF1LK ; SIK ; SNF1LK
Categories	Elisa
Function	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase SIK1
Subcellular Location	Cytoplasm Nucleus Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.
Detection Range	0.156-10ng/mL
Entryname	SIK1_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase SIK1
Sensitivity	0.1ng/ml
Sequence	50: MVIMSEFSAD ; PAGQGQGQQK ; PLRVGFYDIE ; RTLGKGNFAV ; VKLARHRVTK ; 100: TQVAIKIIDK ; TRLDSSNLEK ; IYREVQLMKL ; LNHPHIIKLY ; QVMETKDMLY ; 150: IVTEFAKNGE ; MFDYLTSNGH ; LSENEARKKF ; WQILSAVEYC ; HDHHIVHRDL ; 200: KTENLLLDGN ; MDIKLADFGF ; GNFYKSGEPL ; STWCGSPPYA ; APEVFEGKEY ; 250: EGPQLDIWSL ; GVVLYVLVCG ; SLPFDGPNLP ; TLRQRVLEGR ; FRIPFFMSQD ; 300: CESLIRRMLV ; VDPARRITIA ; QIRQHRWMRA ; EPCLPGPACP ; AFSAHSYTSN ; 350: LGDYDEQALG ; IMQTLGVDRQ ; RTVESLQNSS ; YNHFAAIYYL ; LLERLKEYRN ; 400: AQCARPGPAR ; QPRPRSSDLS ; GLEVPQEGLS ; TDPFRPALLC ; PQPQTLVQSV ; 450: LQAEMDCELQ ; SSLQWPLFFP ; VDASCSGVFR ; PRPVSPSSLL ; DTAISEEARQ ; 500: GPGLEEEQDT ; QESLPSSTGR ; RHTLAEVSTR ; LSPLTAPCIV ; VSPSTTASPA ; 550: EGTSSDSCLT ; FSASKSPAGL ; SGTPATQGLL ; GACSPVRLAS ; PFLGSQSATP ; 600: VLQAQGGLGG ; AVLLPVSFQE ; GRRASDTSLT ; QGLKAFRQQL ; RKTTRTKGFL ; 650: GLNKIKGLAR ; QVCQAPASRA ; SRGGLSPFHA ; PAQSPGLHGG ; AAGSREGWSL ; 700: LEEVLEQQRL ; LQLQHHPAAA ; PGCSQAPQPA ; PAPFVIAPCD ; GPGAAPLPST ; 750: LLTSGLPLLP ; PPLLQTGASP ; VASAAQLLDT ; HLHIGTGPTA ; LPAVPPPRLA ; 783: RLAPGCEPLG ; LLQGDCEMED ; LMPCSLGTFV ; LVQ
Sequence Length	783
String	P57059
Sub Unit	Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ.

Uniprot	P57059
Gene Name	SIK1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:150094
Unigene	Hs.282113

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810005	E14381h	96T	$736		Add to Cart

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