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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase pim-1

SKU : BHE13808351

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1997h
Categories	Elisa
Function	May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase pim-1
Subcellular Location	Isoform 1 Cell membrane
Detection Range	31.2-2000pg/mL
Entryname	PIM1_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase pim-1
Sensitivity	15.77pg/mL
Sequence	50: MPHEPHEPLT ; PPFSALPDPA ; GAPSRRQSRQ ; RPQLSSDSPS ; AFRASRSHSR ; 100: NATRSHSHSH ; SPRHSLRHSP ; GSGSCGSSSG ; HRPCADILEV ; GMLLSKINSL ; 150: AHLRAAPCND ; LHATKLAPGK ; EKEPLESQYQ ; VGPLLGSGGF ; GSVYSGIRVS ; 200: DNLPVAIKHV ; EKDRISDWGE ; LPNGTRVPME ; VVLLKKVSSG ; FSGVIRLLDW ; 250: FERPDSFVLI ; LERPEPVQDL ; FDFITERGAL ; QEELARSFFW ; QVLEAVRHCH ; 300: NCGVLHRDIK ; DENILIDLNR ; GELKLIDFGS ; GALLKDTVYT ; DFDGTRVYSP ; 350: PEWIRYHRYH ; GRSAAVWSLG ; ILLYDMVCGD ; IPFEHDEEII ; RGQVFFRQRV ; 400: SSECQHLIRW ; CLALRPSDRP ; TFEEIQNHPW ; MQDVLLPQET ; AEIHLHSLSP ; 404: GPSK
Sequence Length	404
String	P11309
Sub Unit	Binds to RP9. Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Isoform 1, but not isoform 2, binds BMX. Isoform 2 interacts with CDKN1B and FOXO3.

Uniprot	P11309
Gene Name	PIM1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5292
Unigene	Hs.81170

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808351	E1997h	96T	$736		Add to Cart

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