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ELISA Kit for Human Serine/threonine-protein kinase ATR

SKU : BHE13801446

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15117h
Alternative Names	Ataxia telangiectasia and Rad3-related protein ; FRAP-related protein 1 ; FRP1
Categories	Elisa
Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase ATR
Subcellular Location	Nucleus Nucleus PML body Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
Detection Range	0.625-40ng/mL
Entryname	ATR_HUMAN
Method Type	Sandwich
Platform	PF02259
Protein Name	Serine/threonine-protein kinase ATR
Sensitivity	0.326ng/mL
Sequence	50: MGEHGLELAS ; MIPALRELGS ; ATPEEYNTVV ; QKPRQILCQF ; IDRILTDVNV ; 100: VAVELVKKTD ; SQPTSVMLLD ; FIQHIMKSSP ; LMFVNVSGSH ; EAKGSCIEFS ; 150: NWIITRLLRI ; AATPSCHLLH ; KKICEVICSL ; LFLFKSKSPA ; IFGVLTKELL ; 200: QLFEDLVYLH ; RRNVMGHAVE ; WPVVMSRFLS ; QLDEHMGYLQ ; SAPLQLMSMQ ; 250: NLEFIEVTLL ; MVLTRIIAIV ; FFRRQELLLW ; QIGCVLLEYG ; SPKIKSLAIS ; 300: FLTELFQLGG ; LPAQPASTFF ; SSFLELLKHL ; VEMDTDQLKL ; YEEPLSKLIK ; 350: TLFPFEAEAY ; RNIEPVYLNM ; LLEKLCVMFE ; DGVLMRLKSD ; LLKAALCHLL ; 400: QYFLKFVPAG ; YESALQVRKV ; YVRNICKALL ; DVLGIEVDAE ; YLLGPLYAAL ; 450: KMESMEIIEE ; IQCQTQQENL ; SSNSDGISPK ; RRRLSSSLNP ; SKRAPKQTEE ; 500: IKHVDMNQKS ; ILWSALKQKA ; ESLQISLEYS ; GLKNPVIEML ; EGIAVVLQLT ; 550: ALCTVHCSHQ ; NMNCRTFKDC ; QHKSKKKPSV ; VITWMSLDFY ; TKVLKSCRSL ; 600: LESVQKLDLE ; ATIDKVVKIY ; DALIYMQVNS ; SFEDHILEDL ; CGMLSLPWIY ; 650: SHSDDGCLKL ; TTFAANLLTL ; SCRISDSYSP ; QAQSRCVFLL ; TLFPRRIFLE ; 700: WRTAVYNWAL ; QSSHEVIRAS ; CVSGFFILLQ ; QQNSCNRVPK ; ILIDKVKDDS ; 750: DIVKKEFASI ; LGQLVCTLHG ; MFYLTSSLTE ; PFSEHGHVDL ; FCRNLKATSQ ; 800: HECSSSQLKA ; SVCKPFLFLL ; KKKIPSPVKL ; AFIDNLHHLC ; KHLDFREDET ; 850: DVKAVLGTLL ; NLMEDPDKDV ; RVAFSGNIKH ; ILESLDSEDG ; FIKELFVLRM ; 900: KEAYTHAQIS ; RNNELKDTLI ; LTTGDIGRAA ; KGDLVPFALL ; HLLHCLLSKS ; 950: ASVSGAAYTE ; IRALVAAKSV ; KLQSFFSQYK ; KPICQFLVES ; LHSSQMTALP ; 1000: NTPCQNADVR ; KQDVAHQREM ; ALNTLSEIAN ; VFDFPDLNRF ; LTRTLQVLLP ; 1050: DLAAKASPAA ; SALIRTLGKQ ; LNVNRREILI ; NNFKYIFSHL ; VCSCSKDELE ; 1100: RALHYLKNET ; EIELGSLLRQ ; DFQGLHNELL ; LRIGEHYQQV ; FNGLSILASF ; 1150: ASSDDPYQGP ; RDIISPELMA ; DYLQPKLLGI ; LAFFNMQLLS ; SSVGIEDKKM ; 1200: ALNSLMSLMK ; LMGPKHVSSV ; RVKMMTTLRT ; GLRFKDDFPE ; LCCRAWDCFV ; 1250: RCLDHACLGS ; LLSHVIVALL ; PLIHIQPKET ; AAIFHYLIIE ; NRDAVQDFLH ; 1300: EIYFLPDHPE ; LKKIKAVLQE ; YRKETSESTD ; LQTTLQLSMK ; AIQHENVDVR ; 1350: IHALTSLKET ; LYKNQEKLIK ; YATDSETVEP ; IISQLVTVLL ; KGCQDANSQA ; 1400: RLLCGECLGE ; LGAIDPGRLD ; FSTTETQGKD ; FTFVTGVEDS ; SFAYGLLMEL ; 1450: TRAYLAYADN ; SRAQDSAAYA ; IQELLSIYDC ; REMETNGPGH ; QLWRRFPEHV ; 1500: REILEPHLNT ; RYKSSQKSTD ; WSGVKKPIYL ; SKLGSNFAEW ; SASWAGYLIT ; 1550: KVRHDLASKI ; FTCCSIMMKH ; DFKVTIYLLP ; HILVYVLLGC ; NQEDQQEVYA ; 1600: EIMAVLKHDD ; QHTINTQDIA ; SDLCQLSTQT ; VFSMLDHLTQ ; WARHKFQALK ; 1650: AEKCPHSKSN ; RNKVDSMVST ; VDYEDYQSVT ; RFLDLIPQDT ; LAVASFRSKA ; 1700: YTRAVMHFES ; FITEKKQNIQ ; EHLGFLQKLY ; AAMHEPDGVA ; GVSAIRKAEP ; 1750: SLKEQILEHE ; SLGLLRDATA ; CYDRAIQLEP ; DQIIHYHGVV ; KSMLGLGQLS ; 1800: TVITQVNGVH ; ANRSEWTDEL ; NTYRVEAAWK ; LSQWDLVENY ; LAADGKSTTW ; 1850: SVRLGQLLLS ; AKKRDITAFY ; DSLKLVRAEQ ; IVPLSAASFE ; RGSYQRGYEY ; 1900: IVRLHMLCEL ; EHSIKPLFQH ; SPGDSSQEDS ; LNWVARLEMT ; QNSYRAKEPI ; 1950: LALRRALLSL ; NKRPDYNEMV ; GECWLQSARV ; ARKAGHHQTA ; YNALLNAGES ; 2000: RLAELYVERA ; KWLWSKGDVH ; QALIVLQKGV ; ELCFPENETP ; PEGKNMLIHG ; 2050: RAMLLVGRFM ; EETANFESNA ; IMKKYKDVTA ; CLPEWEDGHF ; YLAKYYDKLM ; 2100: PMVTDNKMEK ; QGDLIRYIVL ; HFGRSLQYGN ; QFIYQSMPRM ; LTLWLDYGTK ; 2150: AYEWEKAGRS ; DRVQMRNDLG ; KINKVITEHT ; NYLAPYQFLT ; AFSQLISRIC ; 2200: HSHDEVFVVL ; MEIIAKVFLA ; YPQQAMWMMT ; AVSKSSYPMR ; VNRCKEILNK ; 2250: AIHMKKSLEK ; FVGDATRLTD ; KLLELCNKPV ; DGSSSTLSMS ; THFKMLKKLV ; 2300: EEATFSEILI ; PLQSVMIPTL ; PSILGTHANH ; ASHEPFPGHW ; AYIAGFDDMV ; 2350: EILASLQKPK ; KISLKGSDGK ; FYIMMCKPKD ; DLRKDCRLME ; FNSLINKCLR ; 2400: KDAESRRREL ; HIRTYAVIPL ; NDECGIIEWV ; NNTAGLRPIL ; TKLYKEKGVY ; 2450: MTGKELRQCM ; LPKSAALSEK ; LKVFREFLLP ; RHPPIFHEWF ; LRTFPDPTSW ; 2500: YSSRSAYCRS ; TAVMSMVGYI ; LGLGDRHGEN ; ILFDSLTGEC ; VHVDFNCLFN ; 2550: KGETFEVPEI ; VPFRLTHNMV ; NGMGPMGTEG ; LFRRACEVTM ; RLMRDQREPL ; 2600: MSVLKTFLHD ; PLVEWSKPVK ; GHSKAPLNET ; GEVVNEKAKT ; HVLDIEQRLQ ; 2644: GVIKTRNRVT ; GLPLSIEGHV ; HYLIQEATDE ; NLLCQMYLGW ; TPYM
Sequence Length	2644
String	Q13535
Sub Unit	Forms an heterodimer with ATRIP. Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with BCR-ABL after genotoxic stress. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164. Interacts with TELO2 AND TTI1.

Uniprot	Q13535
Gene Name	ATR
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:545
Unigene	Hs.271791

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BHE13801446	E15117h	96T	$736		Add to Cart

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