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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Sequestosome-1

SKU : BHE13811023

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10081h
Alternative Names	EBI3-associated protein of 60 kDa ; EBIAP ; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa ; Ubiquitin-binding protein p62 ; ORCA ; OSIL
Categories	Elisa
Function	Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Specificity	Natural and recombinant Human Sequestosome-1
Subcellular Location	Cytoplasm Late endosome Nucleus Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.
Detection Range	0.156-10ng/mL
Entryname	SQSTM_HUMAN
Method Type	Sandwich
Platform	PF00564
Protein Name	Sequestosome-1
Sensitivity	0.056ng/mL
Sequence	50: MASLTVKAYL ; LGKEDAAREI ; RRFSFCCSPE ; PEAEAEAAAG ; PGPCERLLSR ; 100: VAALFPALRP ; GGFQAHYRDE ; DGDLVAFSSD ; EELTMAMSYV ; KDDIFRIYIK ; 150: EKKECRRDHR ; PPCAQEAPRN ; MVHPNVICDG ; CNGPVVGTRY ; KCSVCPDYDL ; 200: CSVCEGKGLH ; RGHTKLAFPS ; PFGHLSEGFS ; HSRWLRKVKH ; GHFGWPGWEM ; 250: GPPGNWSPRP ; PRAGEARPGP ; TAESASGPSE ; DPSVNFLKNV ; GESVAAALSP ; 300: LGIEVDIDVE ; HGGKRSRLTP ; VSPESSSTEE ; KSSSQPSSCC ; SDPSKPGGNV ; 350: EGATQSLAEQ ; MRKIALESEG ; RPEEQMESDN ; CSGGDDDWTH ; LSSKEVDPST ; 400: GELQSLQMPE ; SEGPSSLDPS ; QEGPTGLKEA ; ALYPHLPPEA ; DPRLIESLSQ ; 440: MLSMGFSDEG ; GWLTRLLQTK ; NYDIGAALDT ; IQYSKHPPPL ;
Sequence Length	440
String	Q13501
Sub Unit	Homooligomer or heterooligomer; may form homotypic arrays. Interacts directly with PRKCI and PRKCZ (Probable). Forms ternary complexes with PRKCZ and KCNAB2 or PRKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6 (By similarity). Interacts with EBI3, LCK, RASA1, PRKCZ, PRKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MAP2K5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63-polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MAP2K5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. Interacts with TRAF6 and CYLD. Identified in a complex with TRAF6 and CYLD.

Uniprot	Q13501
Gene Name	SQSTM1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8878
Unigene	Hs.724025

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811023	E10081h	96T	$736		Add to Cart

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