VCP-interacting membrane protein ; SELS ; VIMP ; AD-015 ; SBBI8
Categories
Elisa
Function
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
Specificity
Natural and recombinant Human Selenoprotein S
Subcellular Location
Endoplasmic reticulum membrane Single-pass membrane protein Cytoplasm