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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Runt-related transcription factor 2

SKU : BHE13809936

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9029h
Alternative Names	Acute myeloid leukemia 3 protein ; Core-binding factor subunit alpha-1 ; CBF-alpha-1 ; Oncogene AML-3 ; Osteoblast-specific transcription factor 2 ; OSF-2 ; Polyomavirus enhancer-binding protein 2 alpha A subunit ; PEA2-alpha A ; SL3-3 enhancer factor 1 alpha A subunit ; SL3/AKV core-binding factor alpha A subunit ; AML3 ; CBFA1 ; OSF2 ; PEBP2A
Categories	Elisa
Function	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Specificity	Natural and recombinant Human Runt-related transcription factor 2
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	RUNX2_HUMAN
Method Type	Sandwich
Platform	PF00853
Protein Name	Runt-related transcription factor 2
Sensitivity	0.056ng/mL
Sequence	50: MASNSLFSTV ; TPCQQNFFWD ; PSTSRRFSPP ; SSSLQPGKMS ; DVSPVVAAQQ ; 100: QQQQQQQQQQ ; QQQQQQQQQQ ; QEAAAAAAAA ; AAAAAAAAAV ; PRLRPPHDNR ; 150: TMVEIIADHP ; AELVRTDSPN ; FLCSVLPSHW ; RCNKTLPVAF ; KVVALGEVPD ; 200: GTVVTVMAGN ; DENYSAELRN ; ASAVMKNQVA ; RFNDLRFVGR ; SGRGKSFTLT ; 250: ITVFTNPPQV ; ATYHRAIKVT ; VDGPREPRRH ; RQKLDDSKPS ; LFSDRLSDLG ; 300: RIPHPSMRVG ; VPPQNPRPSL ; NSAPSPFNPQ ; GQSQITDPRQ ; AQSSPPWSYD ; 350: QSYPSYLSQM ; TSPSIHSTTP ; LSSTRGTGLP ; AITDVPRRIS ; DDDTATSDFC ; 400: LWPSTLSKKS ; QAGASELGPF ; SDPRQFPSIS ; SLTESRFSNP ; RMHYPATFTY ; 450: TPPVTSGMSL ; GMSATTHYHT ; YLPPPYPGSS ; QSQSGPFQTS ; STPYLYYGTS ; 500: SGSYQFPMVP ; GGDRSPSRML ; PPCTTTSNGS ; TLLNPNLPNQ ; NDGVDADGSH ; 521: SSSPTVLNSS ; GRMDESVWRP ; Y
Sequence Length	521
String	Q13950
Sub Unit	Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 and HIPK3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with KAT6A and KAT6B. Binds to cyclin B1 CCNB1.

Uniprot	Q13950
Gene Name	RUNX2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:860
Unigene	Hs.535845

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809936	E9029h	96T	$736		Add to Cart

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