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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Rho-associated protein kinase 2

SKU : BHE13810216

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1852h
Alternative Names	Rho kinase 2 ; Rho-associated ; coiled-coil-containing protein kinase 2 ; Rho-associated ; coiled-coil-containing protein kinase II ; ROCK-II ; p164 ROCK-2 ; KIAA0619
Categories	Elisa
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK (RPS6KA1) during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.
Specificity	Natural and recombinant Human Rho-associated protein kinase 2
Subcellular Location	Cytoplasm Cell membrane Peripheral membrane protein Nucleus Cytoplasm cytoskeleton centrosome Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
Detection Range	1.56-100ng/mL
Entryname	ROCK2_HUMAN
Method Type	Sandwich
Platform	PF02185
Protein Name	Rho-associated protein kinase 2
Sensitivity	0.76ng/mL
Sequence	50: MSRPPPTGKM ; PGAPETAPGD ; GAGASRQRKL ; EALIRDPRSP ; INVESLLDGL ; 100: NSLVLDLDFP ; ALRKNKNIDN ; FLNRYEKIVK ; KIRGLQMKAE ; DYDVVKVIGR ; 150: GAFGEVQLVR ; HKASQKVYAM ; KLLSKFEMIK ; RSDSAFFWEE ; RDIMAFANSP ; 200: WVVQLFYAFQ ; DDRYLYMVME ; YMPGGDLVNL ; MSNYDVPEKW ; AKFYTAEVVL ; 250: ALDAIHSMGL ; IHRDVKPDNM ; LLDKHGHLKL ; ADFGTCMKMD ; ETGMVHCDTA ; 300: VGTPDYISPE ; VLKSQGGDGF ; YGRECDWWSV ; GVFLYEMLVG ; DTPFYADSLV ; 350: GTYSKIMDHK ; NSLCFPEDAE ; ISKHAKNLIC ; AFLTDREVRL ; GRNGVEEIRQ ; 400: HPFFKNDQWH ; WDNIRETAAP ; VVPELSSDID ; SSNFDDIEDD ; KGDVETFPIP ; 450: KAFVGNQLPF ; IGFTYYRENL ; LLSDSPSCRE ; TDSIQSRKNE ; ESQEIQKKLY ; 500: TLEEHLSNEM ; QAKEELEQKC ; KSVNTRLEKT ; AKELEEEITL ; RKSVESALRQ ; 550: LEREKALLQH ; KNAEYQRKAD ; HEADKKRNLE ; NDVNSLKDQL ; EDLKKRNQNS ; 600: QISTEKVNQL ; QRQLDETNAL ; LRTESDTAAR ; LRKTQAESSK ; QIQQLESNNR ; 650: DLQDKNCLLE ; TAKLKLEKEF ; INLQSALESE ; RRDRTHGSEI ; INDLQGRICG ; 700: LEEDLKNGKI ; LLAKVELEKR ; QLQERFTDLE ; KEKSNMEIDM ; TYQLKVIQQS ; 750: LEQEEAEHKA ; TKARLADKNK ; IYESIEEAKS ; EAMKEMEKKL ; LEERTLKQKV ; 800: ENLLLEAEKR ; CSLLDCDLKQ ; SQQKINELLK ; QKDVLNEDVR ; NLTLKIEQET ; 850: QKRCLTQNDL ; KMQTQQVNTL ; KMSEKQLKQE ; NNHLMEMKMN ; LEKQNAELRK ; 900: ERQDADGQMK ; ELQDQLEAEQ ; YFSTLYKTQV ; RELKEECEEK ; TKLGKELQQK ; 950: KQELQDERDS ; LAAQLEITLT ; KADSEQLARS ; IAEEQYSDLE ; KEKIMKELEI ; 1000: KEMMARHKQE ; LTEKDATIAS ; LEETNRTLTS ; DVANLANEKE ; ELNNKLKDVQ ; 1050: EQLSRLKDEE ; ISAAAIKAQF ; EKQLLTERTL ; KTQAVNKLAE ; IMNRKEPVKR ; 1100: GNDTDVRRKE ; KENRKLHMEL ; KSEREKLTQQ ; MIKYQKELNE ; MQAQIAEESQ ; 1150: IRIELQMTLD ; SKDSDIEQLR ; SQLQALHIGL ; DSSSIGSGPG ; DAEADDGFPE ; 1200: SRLEGWLSLP ; VRNNTKKFGW ; VKKYVIVSSK ; KILFYDSEQD ; KEQSNPYMVL ; 1250: DIDKLFHVRP ; VTQTDVYRAD ; AKEIPRIFQI ; LYANEGESKK ; EQEFPVEPVG ; 1300: EKSNYICHKG ; HEFIPTLYHF ; PTNCEACMKP ; LWHMFKPPPA ; LECRRCHIKC ; 1350: HKDHMDKKEE ; IIAPCKVYYD ; ISTAKNLLLL ; ANSTEEQQKW ; VSRLVKKIPK ; 1388: KPPAPDPFAR ; SSPRTSMKIQ ; QNQSIRRPSR ; QLAPNKPS
Sequence Length	1388
String	O75116
Sub Unit	Homodimer. Interacts with IRS1, RHOB and RHOC (By similarity). Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity.

Uniprot	O75116
Gene Name	ROCK2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:9475
Unigene	Hs.681743

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810216	E1852h	96T	$736		Add to Cart

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