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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Retinoic acid receptor RXR-alpha

SKU : BHE13810246

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2043h
Alternative Names	Nuclear receptor subfamily 2 group B member 1 ; Retinoid X receptor alpha ; NR2B1
Categories	Elisa
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Specificity	Natural and recombinant Human Retinoic acid receptor RXR-alpha
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	RXRA_HUMAN
Method Type	Sandwich
Platform	PF00104
Protein Name	Retinoic acid receptor RXR-alpha
Sensitivity	0.082ng/mL
Sequence	50: MDTKHFLPLD ; FSTQVNSSLT ; SPTGRGSMAA ; PSLHPSLGPG ; IGSPGQLHSP ; 100: ISTLSSPING ; MGPPFSVISS ; PMGPHSMSVP ; TTPTLGFSTG ; SPQLSSPMNP ; 150: VSSSEDIKPP ; LGLNGVLKVP ; AHPSGNMASF ; TKHICAICGD ; RSSGKHYGVY ; 200: SCEGCKGFFK ; RTVRKDLTYT ; CRDNKDCLID ; KRQRNRCQYC ; RYQKCLAMGM ; 250: KREAVQEERQ ; RGKDRNENEV ; ESTSSANEDM ; PVERILEAEL ; AVEPKTETYV ; 300: EANMGLNPSS ; PNDPVTNICQ ; AADKQLFTLV ; EWAKRIPHFS ; ELPLDDQVIL ; 350: LRAGWNELLI ; ASFSHRSIAV ; KDGILLATGL ; HVHRNSAHSA ; GVGAIFDRVL ; 400: TELVSKMRDM ; QMDKTELGCL ; RAIVLFNPDS ; KGLSNPAEVE ; ALREKVYASL ; 450: EAYCKHKYPE ; QPGRFAKLLL ; RLPALRSIGL ; KCLEHLFFFK ; LIGDTPIDTF ; 462: LMEMLEAPHQ ; MT
Sequence Length	462
String	P19793
Sub Unit	Homodimer. Heterodimer with RARA; required for ligand-dependent retinoic acid receptor transcriptional activity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG. Interacts with NCOA3 and NCOA6 coactivators. Interacts with FAM120B (By similarity). Interacts with PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts (via the DNA binding domain) with HCV core protein; the interaction enhances the transcriptional activities of the RXRA/RARA and the RXRA/PPARA heterodimers. Interacts with PRMT2.

Uniprot	P19793
Gene Name	RXRA
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6256
Unigene	Hs.590886

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810246	E2043h	96T	$736		Add to Cart

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