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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Retinoic acid receptor alpha

SKU : BHE13809699

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2297h
Alternative Names	Nuclear receptor subfamily 1 group B member 1 ; NR1B1
Categories	Elisa
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing MLL5. Mediates retinoic acid-induced granulopoiesis.
Specificity	Natural and recombinant Human Retinoic acid receptor alpha
Subcellular Location	Nucleus Cytoplasm Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
Detection Range	0.312-20ng/mL
Entryname	RARA_HUMAN
Method Type	Sandwich
Platform	PF00104
Protein Name	Retinoic acid receptor alpha
Sensitivity	0.13ng/mL
Sequence	50: MASNSSSCPT ; PGGGHLNGYP ; VPPYAFFFPP ; MLGGLSPPGA ; LTTLQHQLPV ; 100: SGYSTPSPAT ; IETQSSSSEE ; IVPSPPSPPP ; LPRIYKPCFV ; CQDKSSGYHY ; 150: GVSACEGCKG ; FFRRSIQKNM ; VYTCHRDKNC ; IINKVTRNRC ; QYCRLQKCFE ; 200: VGMSKESVRN ; DRNKKKKEVP ; KPECSESYTL ; TPEVGELIEK ; VRKAHQETFP ; 250: ALCQLGKYTT ; NNSSEQRVSL ; DIDLWDKFSE ; LSTKCIIKTV ; EFAKQLPGFT ; 300: TLTIADQITL ; LKAACLDILI ; LRICTRYTPE ; QDTMTFSDGL ; TLNRTQMHNA ; 350: GFGPLTDLVF ; AFANQLLPLE ; MDDAETGLLS ; AICLICGDRQ ; DLEQPDRVDM ; 400: LQEPLLEALK ; VYVRKRRPSR ; PHMFPKMLMK ; ITDLRSISAK ; GAERVITLKM ; 450: EIPGSMPPLI ; QEMLENSEGL ; DTLSGQPGGG ; GRDGGGLAPP ; PGSCSPSLSP ; 462: SSNRSSPATH ; SP
Sequence Length	462
String	P10276
Sub Unit	Heterodimer; with RXRA. Binds DNA preferentially as a heterodimer. Interacts with CDK7 (By similarity). Interacts with coactivators NCOA3 and NCOA6. Interacts with NCOA7; the interaction requires ligand-binding. Interacts with MLL5. Interacts (via the ligand-binding domain) with PRAME; the interaction is ligand (retinoic acid)-dependent. Interacts with AKT1; the interaction phosphorylates RARA and repressses transactivation. Interacts with PRKAR1A; the interaction negatively regulates RARA transcriptional activity. Interacts with NCOR1 and NCOR2. Interacts with PRMT2. Interacts with LRIF1.

Uniprot	P10276
Gene Name	RARA
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5914
Unigene	Hs.654583

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809699	E2297h	96T	$736		Add to Cart

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