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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Retinoblastoma-like protein 1

SKU : BHE13809571

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1211h
Alternative Names	107 kDa retinoblastoma-associated protein ; p107 ; pRb1
Categories	Elisa
Function	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Specificity	Natural and recombinant Human Retinoblastoma-like protein 1
Subcellular Location	Nucleus
Detection Range	1.56-100ng/mL
Entryname	RBL1_HUMAN
Method Type	Sandwich
Platform	PF11934
Protein Name	Retinoblastoma-like protein 1
Sensitivity	0.98ng/mL
Sequence	50: MFEDKPHAEG ; AAVVAAAGEA ; LQALCQELNL ; DEGSAAEALD ; DFTAIRGNYS ; 100: LEGEVTHWLA ; CSLYVACRKS ; IIPTVGKGIM ; EGNCVSLTRI ; LRSAKLSLIQ ; 150: FFSKMKKWMD ; MSNLPQEFRE ; RIERLERNFE ; VSTVIFKKYE ; PIFLDIFQNP ; 200: YEEPPKLPRS ; RKQRRIPCSV ; KDLFNFCWTL ; FVYTKGNFRM ; IGDDLVNSYH ; 250: LLLCCLDLIF ; ANAIMCPNRQ ; DLLNPSFKGL ; PSDFHTADFT ; ASEEPPCIIA ; 300: VLCELHDGLL ; VEAKGIKEHY ; FKPYISKLFD ; RKILKGECLL ; DLSSFTDNSK ; 350: AVNKEYEEYV ; LTVGDFDERI ; FLGADAEEEI ; GTPRKFTRDT ; PLGKLTAQAN ; 400: VEYNLQQHFE ; KKRSFAPSTP ; LTGRRYLREK ; EAVITPVASA ; TQSVSRLQSI ; 450: VAGLKNAPSD ; QLINIFESCV ; RNPVENIMKI ; LKGIGETFCQ ; HYTQSTDEQP ; 500: GSHIDFAVNR ; LKLAEILYYK ; ILETVMVQET ; RRLHGMDMSV ; LLEQDIFHRS ; 550: LMACCLEIVL ; FAYSSPRTFP ; WIIEVLNLQP ; FYFYKVIEVV ; IRSEEGLSRD ; 600: MVKHLNSIEE ; QILESLAWSH ; DSALWEALQV ; SANKVPTCEE ; VIFPNNFETG ; 650: NGGNVQGHLP ; LMPMSPLMHP ; RVKEVRTDSG ; SLRRDMQPLS ; PISVHERYSS ; 700: PTAGSAKRRL ; FGEDPPKEML ; MDKIITEGTK ; LKIAPSSSIT ; AENVSILPGQ ; 750: TLLTMATAPV ; TGTTGHKVTI ; PLHGVANDAG ; EITLIPLSMN ; TNQESKVKSP ; 800: VSLTAHSLIG ; ASPKQTNLTK ; AQEVHSTGIN ; RPKRTGSLAL ; FYRKVYHLAS ; 850: VRLRDLCLKL ; DVSNELRRKI ; WTCFEFTLVH ; CPDLMKDRHL ; DQLLLCAFYI ; 900: MAKVTKEERT ; FQEIMKSYRN ; QPQANSHVYR ; SVLLKSIPRE ; VVAYNKNIND ; 950: DFEMIDCDLE ; DATKTPDCSS ; GPVKEERGDL ; IKFYNTIYVG ; RVKSFALKYD ; 1000: LANQDHMMDA ; PPLSPFPHIK ; QQPGSPRRIS ; QQHSIYISPH ; KNGSGLTPRS ; 1050: ALLYKFNGSP ; SKSLKDINNM ; IRQGEQRTKK ; RVIAIDSDAE ; SPAKRVCQEN ; 1068: DDVLLKRLQD ; VVSERANH
Sequence Length	1068
String	P28749
Sub Unit	Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with KDM5A. Interacts with SV40 and JC virus large T antigens.

Uniprot	P28749
Gene Name	RBL1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5933
Unigene	Hs.207745

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809571	E1211h	96T	$736		Add to Cart

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