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ELISA Kit for Human Retinal-specific ATP-binding cassette transporter

SKU : BHE13800253

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10399h
Alternative Names	ATP-binding cassette sub-family A member 4 ; RIM ABC transporter ; RIM protein ; Stargardt disease protein ; ABCR
Categories	Elisa
Function	In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
Specificity	Natural and recombinant Human Retinal-specific ATP-binding cassette transporter
Subcellular Location	Membrane Multi-pass membrane protein Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.
Detection Range	78-5000pg/mL
Entryname	ABCA4_HUMAN
Method Type	Sandwich
Platform	PF00005
Protein Name	Retinal-specific ATP-binding cassette transporter
Sensitivity	38pg/mL
Sequence	50: MGFVRQIQLL ; LWKNWTLRKR ; QKIRFVVELV ; WPLSLFLVLI ; WLRNANPLYS ; 100: HHECHFPNKA ; MPSAGMLPWL ; QGIFCNVNNP ; CFQSPTPGES ; PGIVSNYNNS ; 150: ILARVYRDFQ ; ELLMNAPESQ ; HLGRIWTELH ; ILSQFMDTLR ; THPERIAGRG ; 200: IRIRDILKDE ; ETLTLFLIKN ; IGLSDSVVYL ; LINSQVRPEQ ; FAHGVPDLAL ; 250: KDIACSEALL ; ERFIIFSQRR ; GAKTVRYALC ; SLSQGTLQWI ; EDTLYANVDF ; 300: FKLFRVLPTL ; LDSRSQGINL ; RSWGGILSDM ; SPRIQEFIHR ; PSMQDLLWVT ; 350: RPLMQNGGPE ; TFTKLMGILS ; DLLCGYPEGG ; GSRVLSFNWY ; EDNNYKAFLG ; 400: IDSTRKDPIY ; SYDRRTTSFC ; NALIQSLESN ; PLTKIAWRAA ; KPLLMGKILY ; 450: TPDSPAARRI ; LKNANSTFEE ; LEHVRKLVKA ; WEEVGPQIWY ; FFDNSTQMNM ; 500: IRDTLGNPTV ; KDFLNRQLGE ; EGITAEAILN ; FLYKGPRESQ ; ADDMANFDWR ; 550: DIFNITDRTL ; RLVNQYLECL ; VLDKFESYND ; ETQLTQRALS ; LLEENMFWAG ; 600: VVFPDMYPWT ; SSLPPHVKYK ; IRMDIDVVEK ; TNKIKDRYWD ; SGPRADPVED ; 650: FRYIWGGFAY ; LQDMVEQGIT ; RSQVQAEAPV ; GIYLQQMPYP ; CFVDDSFMII ; 700: LNRCFPIFMV ; LAWIYSVSMT ; VKSIVLEKEL ; RLKETLKNQG ; VSNAVIWCTW ; 750: FLDSFSIMSM ; SIFLLTIFIM ; HGRILHYSDP ; FILFLFLLAF ; STATIMLCFL ; 800: LSTFFSKASL ; AAACSGVIYF ; TLYLPHILCF ; AWQDRMTAEL ; KKAVSLLSPV ; 850: AFGFGTEYLV ; RFEEQGLGLQ ; WSNIGNSPTE ; GDEFSFLLSM ; QMMLLDAAVY ; 900: GLLAWYLDQV ; FPGDYGTPLP ; WYFLLQESYW ; LGGEGCSTRE ; ERALEKTEPL ; 950: TEETEDPEHP ; EGIHDSFFER ; EHPGWVPGVC ; VKNLVKIFEP ; CGRPAVDRLN ; 1000: ITFYENQITA ; FLGHNGAGKT ; TTLSILTGLL ; PPTSGTVLVG ; GRDIETSLDA ; 1050: VRQSLGMCPQ ; HNILFHHLTV ; AEHMLFYAQL ; KGKSQEEAQL ; EMEAMLEDTG ; 1100: LHHKRNEEAQ ; DLSGGMQRKL ; SVAIAFVGDA ; KVVILDEPTS ; GVDPYSRRSI ; 1150: WDLLLKYRSG ; RTIIMSTHHM ; DEADLLGDRI ; AIIAQGRLYC ; SGTPLFLKNC ; 1200: FGTGLYLTLV ; RKMKNIQSQR ; KGSEGTCSCS ; SKGFSTTCPA ; HVDDLTPEQV ; 1250: LDGDVNELMD ; VVLHHVPEAK ; LVECIGQELI ; FLLPNKNFKH ; RAYASLFREL ; 1300: EETLADLGLS ; SFGISDTPLE ; EIFLKVTEDS ; DSGPLFAGGA ; QQKRENVNPR ; 1350: HPCLGPREKA ; GQTPQDSNVC ; SPGAPAAHPE ; GQPPPEPECP ; GPQLNTGTQL ; 1400: VLQHVQALLV ; KRFQHTIRSH ; KDFLAQIVLP ; ATFVFLALML ; SIVIPPFGEY ; 1450: PALTLHPWIY ; GQQYTFFSMD ; EPGSEQFTVL ; ADVLLNKPGF ; GNRCLKEGWL ; 1500: PEYPCGNSTP ; WKTPSVSPNI ; TQLFQKQKWT ; QVNPSPSCRC ; STREKLTMLP ; 1550: ECPEGAGGLP ; PPQRTQRSTE ; ILQDLTDRNI ; SDFLVKTYPA ; LIRSSLKSKF ; 1600: WVNEQRYGGI ; SIGGKLPVVP ; ITGEALVGFL ; SDLGRIMNVS ; GGPITREASK ; 1650: EIPDFLKHLE ; TEDNIKVWFN ; NKGWHALVSF ; LNVAHNAILR ; ASLPKDRSPE ; 1700: EYGITVISQP ; LNLTKEQLSE ; ITVLTTSVDA ; VVAICVIFSM ; SFVPASFVLY ; 1750: LIQERVNKSK ; HLQFISGVSP ; TTYWVTNFLW ; DIMNYSVSAG ; LVVGIFIGFQ ; 1800: KKAYTSPENL ; PALVALLLLY ; GWAVIPMMYP ; ASFLFDVPST ; AYVALSCANL ; 1850: FIGINSSAIT ; FILELFENNR ; TLLRFNAVLR ; KLLIVFPHFC ; LGRGLIDLAL ; 1900: SQAVTDVYAR ; FGEEHSANPF ; HWDLIGKNLF ; AMVVEGVVYF ; LLTLLVQRHF ; 1950: FLSQWIAEPT ; KEPIVDEDDD ; VAEERQRIIT ; GGNKTDILRL ; HELTKIYPGT ; 2000: SSPAVDRLCV ; GVRPGECFGL ; LGVNGAGKTT ; TFKMLTGDTT ; VTSGDATVAG ; 2050: KSILTNISEV ; HQNMGYCPQF ; DAIDELLTGR ; EHLYLYARLR ; GVPAEEIEKV ; 2100: ANWSIKSLGL ; TVYADCLAGT ; YSGGNKRKLS ; TAIALIGCPP ; LVLLDEPTTG ; 2150: MDPQARRMLW ; NVIVSIIREG ; RAVVLTSHSM ; EECEALCTRL ; AIMVKGAFRC ; 2200: MGTIQHLKSK ; FGDGYIVTMK ; IKSPKDDLLP ; DLNPVEQFFQ ; GNFPGSVQRE ; 2250: RHYNMLQFQV ; SSSSLARIFQ ; LLLSHKDSLL ; IEEYSVTQTT ; LDQVFVNFAK ; 2273: QQTESHDLPL ; HPRAAGASRQ ; AQD
Sequence Length	2273
String	P78363

Uniprot	P78363
Gene Name	ABCA4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:24
Unigene	Hs.416707

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