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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Receptor tyrosine-protein kinase erbB-2

SKU : BHE13804358

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1867h
Alternative Names	Metastatic lymph node gene 19 protein ; MLN 19 ; Proto-oncogene Neu ; Proto-oncogene c-ErbB-2 ; Tyrosine kinase-type cell surface receptor HER2 ; p185erbB2 ; CD340 ; HER2 ; MLN19 ; NEU ; NGL
Categories	Elisa
Function	In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Specificity	Natural and recombinant Human Receptor tyrosine-protein kinase erbB-2
Subcellular Location	Isoform 3 Cytoplasm Nucleus
Detection Range	0.312-20ng/mL
Entryname	ERBB2_HUMAN
Method Type	Sandwich
Platform	PF00757
Protein Name	Receptor tyrosine-protein kinase erbB-2
Sensitivity	0.1ng/mL
Sequence	50: MELAALCRWG ; LLLALLPPGA ; ASTQVCTGTD ; MKLRLPASPE ; THLDMLRHLY ; 100: QGCQVVQGNL ; ELTYLPTNAS ; LSFLQDIQEV ; QGYVLIAHNQ ; VRQVPLQRLR ; 150: IVRGTQLFED ; NYALAVLDNG ; DPLNNTTPVT ; GASPGGLREL ; QLRSLTEILK ; 200: GGVLIQRNPQ ; LCYQDTILWK ; DIFHKNNQLA ; LTLIDTNRSR ; ACHPCSPMCK ; 250: GSRCWGESSE ; DCQSLTRTVC ; AGGCARCKGP ; LPTDCCHEQC ; AAGCTGPKHS ; 300: DCLACLHFNH ; SGICELHCPA ; LVTYNTDTFE ; SMPNPEGRYT ; FGASCVTACP ; 350: YNYLSTDVGS ; CTLVCPLHNQ ; EVTAEDGTQR ; CEKCSKPCAR ; VCYGLGMEHL ; 400: REVRAVTSAN ; IQEFAGCKKI ; FGSLAFLPES ; FDGDPASNTA ; PLQPEQLQVF ; 450: ETLEEITGYL ; YISAWPDSLP ; DLSVFQNLQV ; IRGRILHNGA ; YSLTLQGLGI ; 500: SWLGLRSLRE ; LGSGLALIHH ; NTHLCFVHTV ; PWDQLFRNPH ; QALLHTANRP ; 550: EDECVGEGLA ; CHQLCARGHC ; WGPGPTQCVN ; CSQFLRGQEC ; VEECRVLQGL ; 600: PREYVNARHC ; LPCHPECQPQ ; NGSVTCFGPE ; ADQCVACAHY ; KDPPFCVARC ; 650: PSGVKPDLSY ; MPIWKFPDEE ; GACQPCPINC ; THSCVDLDDK ; GCPAEQRASP ; 700: LTSIISAVVG ; ILLVVVLGVV ; FGILIKRRQQ ; KIRKYTMRRL ; LQETELVEPL ; 750: TPSGAMPNQA ; QMRILKETEL ; RKVKVLGSGA ; FGTVYKGIWI ; PDGENVKIPV ; 800: AIKVLRENTS ; PKANKEILDE ; AYVMAGVGSP ; YVSRLLGICL ; TSTVQLVTQL ; 850: MPYGCLLDHV ; RENRGRLGSQ ; DLLNWCMQIA ; KGMSYLEDVR ; LVHRDLAARN ; 900: VLVKSPNHVK ; ITDFGLARLL ; DIDETEYHAD ; GGKVPIKWMA ; LESILRRRFT ; 950: HQSDVWSYGV ; TVWELMTFGA ; KPYDGIPARE ; IPDLLEKGER ; LPQPPICTID ; 1000: VYMIMVKCWM ; IDSECRPRFR ; ELVSEFSRMA ; RDPQRFVVIQ ; NEDLGPASPL ; 1050: DSTFYRSLLE ; DDDMGDLVDA ; EEYLVPQQGF ; FCPDPAPGAG ; GMVHHRHRSS ; 1100: STRSGGGDLT ; LGLEPSEEEA ; PRSPLAPSEG ; AGSDVFDGDL ; GMGAAKGLQS ; 1150: LPTHDPSPLQ ; RYSEDPTVPL ; PSETDGYVAP ; LTCSPQPEYV ; NQPDVRPQPP ; 1200: SPREGPLPAA ; RPAGATLERP ; KTLSPGKNGV ; VKDVFAFGGA ; VENPEYLTPQ ; 1250: GGAAPQPHPP ; PAFSPAFDNL ; YYWDQDPPER ; GAPPSTFKGT ; PTAENPEYLG ; 1255: LDVPV
Sequence Length	1255
String	P04626
Sub Unit	Homodimer. Heterodimer with ERBB3. Heterodimer with each of the other ERBB receptors (Potential). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1248) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, RPA94 and ACTB.

Uniprot	P04626
Gene Name	ERBB2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2064
Unigene	Hs.446352

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804358	E1867h	96T	$536		Add to Cart

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