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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 3

SKU : BHE13810421

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11168h
Alternative Names	RIP-like protein kinase 3 ; Receptor-interacting protein 3 ; RIP-3 ; RIP3
Categories	Elisa
Function	Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Specificity	Natural and recombinant Human Receptor-interacting serine/threonine-protein kinase 3
Subcellular Location	Cytoplasm Cell membrane Mitochondrion
Detection Range	0.156-10ng/mL
Entryname	RIPK3_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Receptor-interacting serine/threonine-protein kinase 3
Sensitivity	0.086ng/mL
Sequence	50: MSCVKLWPSG ; APAPLVSIEE ; LENQELVGKG ; GFGTVFRAQH ; RKWGYDVAVK ; 100: IVNSKAISRE ; VKAMASLDNE ; FVLRLEGVIE ; KVNWDQDPKP ; ALVTKFMENG ; 150: SLSGLLQSQC ; PRPWPLLCRL ; LKEVVLGMFY ; LHDQNPVLLH ; RDLKPSNVLL ; 200: DPELHVKLAD ; FGLSTFQGGS ; QSGTGSGEPG ; GTLGYLAPEL ; FVNVNRKAST ; 250: ASDVYSFGIL ; MWAVLAGREV ; ELPTEPSLVY ; EAVCNRQNRP ; SLAELPQAGP ; 300: ETPGLEGLKE ; LMQLCWSSEP ; KDRPSFQECL ; PKTDEVFQMV ; ENNMNAAVST ; 350: VKDFLSQLRS ; SNRRFSIPES ; GQGGTEMDGF ; RRTIENQHSR ; NDVMVSEWLN ; 400: KLNLEEPPSS ; VPKKCPSLTK ; RSRAQEEQVP ; QAWTAGTSSD ; SMAQPPQTPE ; 450: TSTFRNQMPS ; PTSTGTPSPG ; PRGNQGAERQ ; GMNWSCRTPE ; PNPVTGRPLV ; 500: NIYNCSGVQV ; GDNNYLTMQQ ; TTALPTWGLA ; PSGKGRGLQH ; PPPVGSQEGP ; 518: KDPEAWSRPQ ; GWYNHSGK
Sequence Length	518
String	Q9Y572
Sub Unit	Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Binds TRAF2 is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes.

Uniprot	Q9Y572
Gene Name	RIPK3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:11035
Unigene	Hs.268551

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810421	E11168h	96T	$736		Add to Cart

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