JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 1

SKU : BHE13809956

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E15191h
Alternative Names	Cell death protein RIP ; Receptor-interacting protein 1 ; RIP-1 ; Serine/threonine-protein kinase RIP ; RIP ; RIP1
Categories	Elisa
Function	Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
Specificity	Natural and recombinant Human Receptor-interacting serine/threonine-protein kinase 1
Subcellular Location	Cytoplasm Cell membrane
Detection Range	31.2-2000pg/mL
Entryname	RIPK1_HUMAN
Method Type	Sandwich
Platform	PF00531
Protein Name	Receptor-interacting serine/threonine-protein kinase 1
Sensitivity	15.68pg/mL
Sequence	50: MQPDMSLNVI ; KMKSSDFLES ; AELDSGGFGK ; VSLCFHRTQG ; LMIMKTVYKG ; 100: PNCIEHNEAL ; LEEAKMMNRL ; RHSRVVKLLG ; VIIEEGKYSL ; VMEYMEKGNL ; 150: MHVLKAEMST ; PLSVKGRIIL ; EIIEGMCYLH ; GKGVIHKDLK ; PENILVDNDF ; 200: HIKIADLGLA ; SFKMWSKLNN ; EEHNELREVD ; GTAKKNGGTL ; YYMAPEHLND ; 250: VNAKPTEKSD ; VYSFAVVLWA ; IFANKEPYEN ; AICEQQLIMC ; IKSGNRPDVD ; 300: DITEYCPREI ; ISLMKLCWEA ; NPEARPTFPG ; IEEKFRPFYL ; SQLEESVEED ; 350: VKSLKKEYSN ; ENAVVKRMQS ; LQLDCVAVPS ; SRSNSATEQP ; GSLHSSQGLG ; 400: MGPVEESWFA ; PSLEHPQEEN ; EPSLQSKLQD ; EANYHLYGSR ; MDRQTKQQPR ; 450: QNVAYNREEE ; RRRRVSHDPF ; AQQRPYENFQ ; NTEGKGTAYS ; SAASHGNAVH ; 500: QPSGLTSQPQ ; VLYQNNGLYS ; SHGFGTRPLD ; PGTAGPRVWY ; RPIPSHMPSL ; 550: HNIPVPETNY ; LGNTPTMPFS ; SLPPTDESIK ; YTIYNSTGIQ ; IGAYNYMEIG ; 600: GTSSSLLDST ; NTNFKEEPAA ; KYQAIFDNTT ; SLTDKHLDPI ; RENLGKHWKN ; 650: CARKLGFTQS ; QIDEIDHDYE ; RDGLKEKVYQ ; MLQKWVMREG ; IKGATVGKLA ; 671: QALHQCSRID ; LLSSLIYVSQ ; N
Sequence Length	671
String	Q13546
Sub Unit	Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1.

Uniprot	Q13546
Gene Name	RIPK1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8737
Unigene	Hs.519842

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13809956	E15191h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.