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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Protein KIBRA

SKU : BHE13805788

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2983h
Alternative Names	HBeAg-binding protein 3 ; Kidney and brain protein ; KIBRA ; WW domain-containing protein 1 ; KIAA0869
Categories	Elisa
Function	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance.
Specificity	Natural and recombinant Human Protein KIBRA
Subcellular Location	Cytoplasm Cytoplasm perinuclear region Nucleus Cell projection ruffle membrane Co-localizes with PRKCZ in the perinuclear region.
Detection Range	78-5000pg/mL
Entryname	KIBRA_HUMAN
Method Type	Sandwich
Platform	PF00397
Protein Name	Protein KIBRA
Sensitivity	32pg/mL
Sequence	50: MPRPELPLPE ; GWEEARDFDG ; KVYYIDHTNR ; TTSWIDPRDR ; YTKPLTFADC ; 100: ISDELPLGWE ; EAYDPQVGDY ; FIDHNTKTTQ ; IEDPRVQWRR ; EQEHMLKDYL ; 150: VVAQEALSAQ ; KEIYQVKQQR ; LELAQQEYQQ ; LHAVWEHKLG ; SQVSLVSGSS ; 200: SSSKYDPEIL ; KAEIATAKSR ; VNKLKREMVH ; LQHELQFKER ; GFQTLKKIDK ; 250: KMSDAQGSYK ; LDEAQAVLRE ; TKAIKKAITC ; GEKEKQDLIK ; SLAMLKDGFR ; 300: TDRGSHSDLW ; SSSSSLESSS ; FPLPKQYLDV ; SSQTDISGSF ; GINSNNQLAE ; 350: KVRLRLRYEE ; AKRRIANLKI ; QLAKLDSEAW ; PGVLDSERDR ; LILINEKEEL ; 400: LKEMRFISPR ; KWTQGEVEQL ; EMARKRLEKD ; LQAARDTQSK ; ALTERLKLNS ; 450: KRNQLVRELE ; EATRQVATLH ; SQLKSLSSSM ; QSLSSGSSPG ; SLTSSRGSLV ; 500: ASSLDSSTSA ; SFTDLYYDPF ; EQLDSELQSK ; VEFLLLEGAT ; GFRPSGCITT ; 550: IHEDEVAKTQ ; KAEGGGRLQA ; LRSLSGTPKS ; MTSLSPRSSL ; SSPSPPCSPL ; 600: MADPLLAGDA ; FLNSLEFEDP ; ELSATLCELS ; LGNSAQERYR ; LEEPGTEGKQ ; 650: LGQAVNTAQG ; CGLKVACVSA ; AVSDESVAGD ; SGVYEASVQR ; LGASEAAAFD ; 700: SDESEAVGAT ; RIQIALKYDE ; KNKQFAILII ; QLSNLSALLQ ; QQDQKVNIRV ; 750: AVLPCSESTT ; CLFRTRPLDA ; SDTLVFNEVF ; WVSMSYPALH ; QKTLRVDVCT ; 800: TDRSHLEECL ; GGAQISLAEV ; CRSGERSTRW ; YNLLSYKYLK ; KQSRELKPVG ; 850: VMAPASGPAS ; TDAVSALLEQ ; TAVELEKRQE ; GRSSTQTLED ; SWRYEETSEN ; 900: EAVAEEEEEE ; VEEEEGEEDV ; FTEKASPDMD ; GYPALKVDKE ; TNTETPAPSP ; 950: TVVRPKDRRV ; GTPSQGPFLR ; GSTIIRSKTF ; SPGPQSQYVC ; RLNRSDSDSS ; 1000: TLSKKPPFVR ; NSLERRSVRM ; KRPSSVKSLR ; SERLIRTSLD ; LELDLQATRT ; 1050: WHSQLTQEIS ; VLKELKEQLE ; QAKSHGEKEL ; PQWLREDERF ; RLLLRMLEKR ; 1100: QMDRAEHKGE ; LQTDKMMRAA ; AKDVHRLRGQ ; SCKEPPEVQS ; FREKMAFFTR ; 1113: PRMNIPALSA ; DDV
Sequence Length	1113
String	Q8IX03
Sub Unit	Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.

Uniprot	Q8IX03
Gene Name	WWC1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:23286
Unigene	Hs.484047

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805788	E2983h	96T	$736		Add to Cart

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