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ELISA Kit for Human Protein CYR61

SKU : BHE13803709

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0494h
Alternative Names	CCN family member 1 ; Cysteine-rich angiogenic inducer 61 ; Insulin-like growth factor-binding protein 10 ; IBP-10 ; Protein GIG1 ; CCN1 ; GIG1 ; IGFBP10
Categories	Elisa
Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Specificity	Natural and recombinant Human Protein CYR61
Subcellular Location	Secreted
Detection Range	31.2-2000pg/mL
Entryname	CYR61_HUMAN
Method Type	Sandwich
Platform	PF00007
Protein Name	Protein CYR61
Sensitivity	10pg/mL
Sequence	50: MSSRIARALA ; LVVTLLHLTR ; LALSTCPAAC ; HCPLEAPKCA ; PGVGLVRDGC ; 100: GCCKVCAKQL ; NEDCSKTQPC ; DHTKGLECNF ; GASSTALKGI ; CRAQSEGRPC ; 150: EYNSRIYQNG ; ESFQPNCKHQ ; CTCIDGAVGC ; IPLCPQELSL ; PNLGCPNPRL ; 200: VKVTGQCCEE ; WVCDEDSIKD ; PMEDQDGLLG ; KELGFDASEV ; ELTRNNELIA ; 250: VGKGSSLKRL ; PVFGMEPRIL ; YNPLQGQKCI ; VQTTSWSQCS ; KTCGTGISTR ; 300: VTNDNPECRL ; VKETRICEVR ; PCGQPVYSSL ; KKGKKCSKTK ; KSPEPVRFTY ; 350: AGCLSVKKYR ; PKYCGSCVDG ; RCCTPQLTRT ; VKMRFRCEDG ; ETFSKNVMMI ; 381: QSCKCNYNCP ; HANEAAFPFY ; RLFNDIHKFR ; D
Sequence Length	381
String	O00622
Sub Unit	Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

Uniprot	O00622
Gene Name	CYR61
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3491
Unigene	Hs.8867

Reference	1. "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p." Jay P., Berge-Lefranc J.-L., Marsollier C., Mejean C., Taviaux S., Berta P. Oncogene14:1753-1757(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system." Martinerie C., Viegas-Pequignot E., Nguyen V.C., Perbal B. Mol. Pathol.50:310-316(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61." Albrecht C., von Der Kammer H., Mayhaus M., Klaudiny J., Schweizer M., Nitsch R.M. J. Biol. Chem.275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "Human growth-factor inducible gene product CYR61, complete sequence." Kolesnikova T.V., Lau L.F. Submitted (1997-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Placenta. 5. "Cloning of HumCyr61 gene expressing down-regulatedly in rhabdomyosarcoma." Bi A.B., Yu L. Submitted (1997-11) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 6. "Regulation of hCYR61 by vitamin D, serum and cytokines in fetal human osteoblasts." Schuetze N., Lechner A., Groll C., Koehrle J., Jakob F. Submitted (1997-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 7. "Organization and expression of the Cyr61 gene in normal human fibroblasts." Leng E., Malcolm T., Tai G., Estable M., Sadowski I. J. Biomed. Sci.9:59-67(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 8. NIEHS SNPs program Submitted (2003-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TRP-334 9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Lung. tissue: Placenta. tissue: Skin. 10. "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts." Chen C.-C., Mo F.-E., Lau L.F. J. Biol. Chem.276:47329-47337(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN WOUND HEALING 11. "Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3." Kireeva M.L., Lam S.C., Lau L.F. J. Biol. Chem.273:3090-3096(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-V/BETA-3 12. "Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)." Jedsadayanmata A., Chen C.-C., Kireeva M.L., Lau L.F., Lam S.C. J. Biol. Chem.274:24321-24327(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-IIB/BETA-3 13. "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans." Chen N., Chen C.-C., Lau L.F. J. Biol. Chem.275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-6/BETA-1 14. "CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain." Grzeszkiewicz T.M., Kirschling D.J., Chen N., Lau L.F. J. Biol. Chem.276:21943-21950(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-V/BETA-6

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