Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
Specificity
Natural and recombinant Human Prolyl 3-hydroxylase 1
Subcellular Location
Endoplasmic reticulum Secreted extracellular space extracellular matrix Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan.