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ELISA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

SKU : BHE13804914

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13654h
Categories	Elisa
Function	Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli.
Specificity	Natural and recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Subcellular Location	Membrane Multi-pass membrane protein
Detection Range	0.312-20ng/mL
Entryname	HCN4_HUMAN
Method Type	Competitive
Platform	PF00027
Protein Name	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Sensitivity	0.098ng/ml
Sequence	50: MDKLPPSMRK ; RLYSLPQQVG ; AKAWIMDEEE ; DAEEEGAGGR ; QDPSRRSIRL ; 100: RPLPSPSPSA ; AAGGTESRSS ; ALGAADSEGP ; ARGAGKSSTN ; GDCRRFRGSL ; 150: ASLGSRGGGS ; GGTGSGSSHG ; HLHDSAEERR ; LIAEGDASPG ; EDRTPPGLAA ; 200: EPERPGASAQ ; PAASPPPPQQ ; PPQPASASCE ; QPSVDTAIKV ; EGGAAAGDQI ; 250: LPEAEVRLGQ ; AGFMQRQFGA ; MLQPGVNKFS ; LRMFGSQKAV ; EREQERVKSA ; 300: GFWIIHPYSD ; FRFYWDLTML ; LLMVGNLIII ; PVGITFFKDE ; NTTPWIVFNV ; 350: VSDTFFLIDL ; VLNFRTGIVV ; EDNTEIILDP ; QRIKMKYLKS ; WFMVDFISSI ; 400: PVDYIFLIVE ; TRIDSEVYKT ; ARALRIVRFT ; KILSLLRLLR ; LSRLIRYIHQ ; 450: WEEIFHMTYD ; LASAVVRIVN ; LIGMMLLLCH ; WDGCLQFLVP ; MLQDFPDDCW ; 500: VSINNMVNNS ; WGKQYSYALF ; KAMSHMLCIG ; YGRQAPVGMS ; DVWLTMLSMI ; 550: VGATCYAMFI ; GHATALIQSL ; DSSRRQYQEK ; YKQVEQYMSF ; HKLPPDTRQR ; 600: IHDYYEHRYQ ; GKMFDEESIL ; GELSEPLREE ; IINFNCRKLV ; ASMPLFANAD ; 650: PNFVTSMLTK ; LRFEVFQPGD ; YIIREGTIGK ; KMYFIQHGVV ; SVLTKGNKET ; 700: KLADGSYFGE ; ICLLTRGRRT ; ASVRADTYCR ; LYSLSVDNFN ; EVLEEYPMMR ; 750: RAFETVALDR ; LDRIGKKNSI ; LLHKVQHDLN ; SGVFNYQENE ; IIQQIVQHDR ; 800: EMAHCAHRVQ ; AAASATPTPT ; PVIWTPLIQA ; PLQAAAATTS ; VAIALTHHPR ; 850: LPAAIFRPPP ; GSGLGNLGAG ; QTPRHLKRLQ ; SLIPSALGSA ; SPASSPSQVD ; 900: TPSSSSFHIQ ; QLAGFSAPAG ; LSPLLPSSSS ; SPPPGACGSP ; SAPTPSAGVA ; 950: ATTIAGFGHF ; HKALGGSLSS ; SDSPLLTPLQ ; PGARSPQAAQ ; PSPAPPGARG ; 1000: GLGLPEHFLP ; PPPSSRSPSS ; SPGQLGQPPG ; ELSLGLATGP ; LSTPETPPRQ ; 1050: PEPPSLVAGA ; SGGASPVGFT ; PRGGLSPPGH ; SPGPPRTFPS ; APPRASGSHG ; 1100: SLLLPPASSP ; PPPQVPQRRG ; TPPLTPGRLT ; QDLKLISASQ ; PALPQDGAQT ; 1150: LRRASPHSSG ; ESMAAFPLFP ; RAGGGSGGSG ; SSGGLGPPGR ; PYGAIPGQHV ; 1200: TLPRKTSSGS ; LPPPLSLFGA ; RATSSGGPPL ; TAGPQREPGA ; RPEPVRSKLP ; 1203: SNL
Sequence Length	1203
String	Q9Y3Q4
Sub Unit	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.

Uniprot	Q9Y3Q4
Gene Name	HCN4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:10021
Unigene	Hs.86941

Reference	1. "Two pacemaker channels from human heart with profoundly different activation kinetics." Ludwig A., Zong X., Stieber J., Hullin R., Hofmann F., Biel M. EMBO J.18:2323-2329(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY tissue: Heart. 2. "Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis." Seifert R., Scholten A., Gauss R., Mincheva A., Lichter P., Kaupp U.B. Proc. Natl. Acad. Sci. U.S.A.96:9391-9396(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY tissue: Thalamus. 3. "Role of HCN4 channel in preventing ventricular arrhythmia." Ueda K., Hirano Y., Higashiuesato Y., Aizawa Y., Hayashi T., Inagaki N., Tana T., Ohya Y., Takishita S., Muratani H., Hiraoka M., Kimura A. J. Hum. Genet.54:115-121(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN BRGDA8 4. "Structural basis for the cAMP-dependent gating in the human HCN4 channel." Xu X., Vysotskaya Z.V., Liu Q., Zhou L. J. Biol. Chem.285:37082-37091(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 521-739 IN COMPLEX WITH CAMP;NUCLEOTIDE-BINDING;FUNCTION;ENZYME REGULATION;SUBUNIT 5. "Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels." Lolicato M., Nardini M., Gazzarrini S., Moller S., Bertinetti D., Herberg F.W., Bolognesi M., Martin H., Fasolini M., Bertrand J.A., Arrigoni C., Thiel G., Moroni A. J. Biol. Chem.286:44811-44820(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 521-723 IN COMPLEX WITH CAMP;NUCLEOTIDE-BINDING;ENZYME REGULATION;SUBUNIT 6. "Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel." Xu X., Marni F., Wu S., Su Z., Musayev F., Shrestha S., Xie C., Gao W., Liu Q., Zhou L. Structure20:2116-2123(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 521-724;CHARACTERIZATION OF VARIANT SSS2 ARG-672 7. "Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia." Ueda K., Nakamura K., Hayashi T., Inagaki N., Takahashi M., Arimura T., Morita H., Higashiuesato Y., Hirano Y., Yasunami M., Takishita S., Yamashina A., Ohe T., Sunamori M., Hiraoka M., Kimura A. J. Biol. Chem.279:27194-27198(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CARDIAC ARRHYTHMIA ASN-553 8. "Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel." Milanesi R., Baruscotti M., Gnecchi-Ruscone T., DiFrancesco D. N. Engl. J. Med.354:151-157(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SSS2 ARG-672;FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANT SSS2 ARG-672 9. "A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews." Laish-Farkash A., Glikson M., Brass D., Marek-Yagel D., Pras E., Dascal N., Antzelevitch C., Nof E., Reznik H., Eldar M., Luria D. J. Cardiovasc. Electrophysiol.21:1365-1372(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SSS2 VAL-485;CHARACTERIZATION OF VARIANT SSS2 VAL-485

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