Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.
Specificity
Natural and recombinant Human Poliovirus receptor-related protein 4
Subcellular Location
Processed poliovirus receptor-related protein 4 Secreted The secreted form is found in breast tumor patients.