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ELISA Kit for Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

SKU : BHE13809298

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12686h
Alternative Names	Csk-binding protein ; Transmembrane adapter protein PAG ; Transmembrane phosphoprotein Cbp ; CBP ; PAG
Categories	Elisa
Function	Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Specificity	Natural and recombinant Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Subcellular Location	Cell membrane Single-pass type III membrane protein Present in lipid rafts.
Entryname	PHAG1_HUMAN
Protein Name	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Sequence	50: MGPAGSLLGS ; GQMQITLWGS ; LAAVAIFFVI ; TFLIFLCSSC ; DREKKPRQHS ; 100: GDHENLMNVP ; SDKEMFSRSV ; TSLATDAPAS ; SEQNGALTNG ; DILSEDSTLT ; 150: CMQHYEEVQT ; SASDLLDSQD ; STGKPKCHQS ; RELPRIPPES ; AVDTMLTARS ; 200: VDGDQGLGME ; GPYEVLKDSS ; SQENMVEDCL ; YETVKEIKEV ; AAAAHLEKGH ; 250: SGKAKSTSAS ; KELPGPQTEG ; KAEFAEYASV ; DRNKKCRQSV ; NVESILGNSC ; 300: DPEEEAPPPV ; PVKLLDENEN ; LQEKEGGEAE ; ESATDTTSET ; NKRFSSLSYK ; 350: SREEDPTLTE ; EEISAMYSSV ; NKPGQLVNKS ; GQSLTVPEST ; YTSIQGDPQR ; 400: SPSSCNDLYA ; TVKDFEKTPN ; STLPPAGRPS ; EEPEPDYEAI ; QTLNREEEKA ; 432: TLGTNGHHGL ; VPKENDYESI ; SDLQQGRDIT ; RL
Sequence Length	432
Sub Unit	Interacts with FYN. When phosphorylated, interacts with CSK. Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Interacts with LYN on plasma membrane lipid rafts. Identified in a complex with LYN and STAT3.

Uniprot	Q9NWQ8
Gene Name	PAG1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:55824
Unigene	Hs.266175

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809298	E12686h	96T	$736		Add to Cart

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