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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Phosphatidylcholine-sterol acyltransferase

SKU : BHE13806840

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2114h
Alternative Names	Lecithin-cholesterol acyltransferase ; Phospholipid-cholesterol acyltransferase
Categories	Elisa
Function	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms.
Specificity	Natural and recombinant Human Phosphatidylcholine-sterol acyltransferase
Subcellular Location	Secreted Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid.
Detection Range	0.156-10ng/mL
Entryname	LCAT_HUMAN
Method Type	Sandwich
Platform	PF02450
Protein Name	Phosphatidylcholine-sterol acyltransferase
Sensitivity	0.098ng/mL
Sequence	50: MGPPGSPWQW ; VTLLLGLLLP ; PAAPFWLLNV ; LFPPHTTPKA ; ELSNHTRPVI ; 100: LVPGCLGNQL ; EAKLDKPDVV ; NWMCYRKTED ; FFTIWLDLNM ; FLPLGVDCWI ; 150: DNTRVVYNRS ; SGLVSNAPGV ; QIRVPGFGKT ; YSVEYLDSSK ; LAGYLHTLVQ ; 200: NLVNNGYVRD ; ETVRAAPYDW ; RLEPGQQEEY ; YRKLAGLVEE ; MHAAYGKPVF ; 250: LIGHSLGCLH ; LLYFLLRQPQ ; AWKDRFIDGF ; ISLGAPWGGS ; IKPMLVLASG ; 300: DNQGIPIMSS ; IKLKEEQRIT ; TTSPWMFPSR ; MAWPEDHVFI ; STPSFNYTGR ; 350: DFQRFFADLH ; FEEGWYMWLQ ; SRDLLAGLPA ; PGVEVYCLYG ; VGLPTPRTYI ; 400: YDHGFPYTDP ; VGVLYEDGDD ; TVATRSTELC ; GLWQGRQPQP ; VHLLPLHGIQ ; 440: HLNMVFSNLT ; LEHINAILLG ; AYRQGPPASP ; TASPEPPPPE ;
Sequence Length	440
String	P04180

Uniprot	P04180
Gene Name	LCAT
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3931
Unigene	Hs.387239

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806840	E2114h	96T	$736		Add to Cart

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