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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Perforin-1

SKU : BHE13808692

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1317h
Alternative Names	Cytolysin ; Lymphocyte pore-forming protein ; PFP ; PFP
Categories	Elisa
Function	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Specificity	Natural and recombinant Human Perforin-1
Subcellular Location	Cytoplasmic granule lumen Secreted Cell membrane Multi-pass membrane protein Endosome lumen Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.
Detection Range	15.6-1000pg/mL
Entryname	PERF_HUMAN
Method Type	Sandwich
Platform	PF00168
Protein Name	Perforin-1
Sensitivity	10pg/mL
Sequence	50: MAARLLLLGI ; LLLLLPLPVP ; APCHTAARSE ; CKRSHKFVPG ; AWLAGEGVDV ; 100: TSLRRSGSFP ; VDTQRFLRPD ; GTCTLCENAL ; QEGTLQRLPL ; ALTNWRAQGS ; 150: GCQRHVTRAK ; VSSTEAVARD ; AARSIRNDWK ; VGLDVTPKPT ; SNVHVSVAGS ; 200: HSQAANFAAQ ; KTHQDQYSFS ; TDTVECRFYS ; FHVVHTPPLH ; PDFKRALGDL ; 250: PHHFNASTQP ; AYLRLISNYG ; THFIRAVELG ; GRISALTALR ; TCELALEGLT ; 300: DNEVEDCLTV ; EAQVNIGIHG ; SISAEAKACE ; EKKKKHKMTA ; SFHQTYRERH ; 350: SEVVGGHHTS ; INDLLFGIQA ; GPEQYSAWVN ; SLPGSPGLVD ; YTLEPLHVLL ; 400: DSQDPRREAL ; RRALSQYLTD ; RARWRDCSRP ; CPPGRQKSPR ; DPCQCVCHGS ; 450: AVTTQDCCPR ; QRGLAQLEVT ; FIQAWGLWGD ; WFTATDAYVK ; LFFGGQELRT ; 500: STVWDNNNPI ; WSVRLDFGDV ; LLATGGPLRL ; QVWDQDSGRD ; DDLLGTCDQA ; 550: PKSGSHEVRC ; NLNHGHLKFR ; YHARCLPHLG ; GGTCLDYVPQ ; MLLGEPPGNR ; 555: SGAVW
Sequence Length	555
String	P14222
Sub Unit	Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation.

Uniprot	P14222
Gene Name	PRF1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5551
Unigene	Hs.2200

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808692	E1317h	96T	$736		Add to Cart

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