ELISA Kit for Human PCNA-associated factor

Mfr.No.	E8921h
Alternative Names	Hepatitis C virus NS5A-transactivated protein 9 ; HCV NS5A-transactivated protein 9 ; Overexpressed in anaplastic thyroid carcinoma 1 ; OEATC-1 ; PCNA-associated factor of 15 kDa ; PAF15 ; PCNA-clamp-associated factor ; KIAA0101 ; NS5ATP9 ; PAF ; L5
Categories	Elisa
Function	PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Specificity	Natural and recombinant Human PCNA-associated factor
Subcellular Location	Nucleus Cytoplasm Perinuclear region Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region.
Detection Range	0.312-20ng/mL
Entryname	PAF15_HUMAN
Method Type	Sandwich
Protein Name	PCNA-associated factor
Sensitivity	0.1ng/mL
Sequence	50: MVRTKADSVP ; GTYRKVVAAR ; APRKVLGSST ; SATNSTSVSS ; RKAENKYAGG ; 100: NPVCVRPTPK ; WQKGIGEFFR ; LSPKDSEKEN ; QIPEEAGSSG ; LGKAKRKACP ; 111: LQPDHTNDEK ; E
Sequence Length	111
Sub Unit	Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHE13809036	E8921h	96T	$736		Add to Cart