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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Nuclear receptor subfamily 2 group C member 2

SKU : BHE13808431

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10644h
Alternative Names	Orphan nuclear receptor TAK1 ; Orphan nuclear receptor TR4 ; Testicular receptor 4 ; TAK1 ; TR4
Categories	Elisa
Function	Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Specificity	Natural and recombinant Human Nuclear receptor subfamily 2 group C member 2
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	NR2C2_HUMAN
Method Type	Sandwich
Platform	PF00104
Protein Name	Nuclear receptor subfamily 2 group C member 2
Sensitivity	0.081ng/mL
Sequence	50: MTSPSPRIQI ; ISTDSAVASP ; QRIQIVTDQQ ; TGQKIQIVTA ; VDASGSPKQQ ; 100: FILTSPDGAG ; TGKVILASPE ; TSSAKQLIFT ; TSDNLVPGRI ; QIVTDSASVE ; 150: RLLGKTDVQR ; PQVVEYCVVC ; GDKASGRHYG ; AVSCEGCKGF ; FKRSVRKNLT ; 200: YSCRSNQDCI ; INKHHRNRCQ ; FCRLKKCLEM ; GMKMESVQSE ; RKPFDVQREK ; 250: PSNCAASTEK ; IYIRKDLRSP ; LIATPTFVAD ; KDGARQTGLL ; DPGMLVNIQQ ; 300: PLIREDGTVL ; LATDSKAETS ; QGALGTLANV ; VTSLANLSES ; LNNGDTSEIQ ; 350: PEDQSASEIT ; RAFDTLAKAL ; NTTDSSSSPS ; LADGIDTSGG ; GSIHVISRDQ ; 400: STPIIEVEGP ; LLSDTHVTFK ; LTMPSPMPEY ; LNVHYICESA ; SRLLFLSMHW ; 450: ARSIPAFQAL ; GQDCNTSLVR ; ACWNELFTLG ; LAQCAQVMSL ; STILAAIVNH ; 500: LQNSIQEDKL ; SGDRIKQVME ; HIWKLQEFCN ; SMAKLDIDGY ; EYAYLKAIVL ; 550: FSPDHPGLTS ; TSQIEKFQEK ; AQMELQDYVQ ; KTYSEDTYRL ; ARILVRLPAL ; 596: RLMSSNITEE ; LFFTGLIGNV ; SIDSIIPYIL ; KMETAEYNGQ ; ITGASL
Sequence Length	596
String	P49116
Sub Unit	Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the nonphosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (By similarity). Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity.

Uniprot	P49116
Gene Name	NR2C2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7182
Unigene	Hs.555973

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808431	E10644h	96T	$736		Add to Cart

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