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ELISA Kit for Human Nuclear factor NF-kappa-B p100 subunit

SKU : BHE13808139

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9393h
Alternative Names	DNA-binding factor KBF2 ; H2TF1 ; Lymphocyte translocation chromosome 10 protein ; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 ; Oncogene Lyt-10 ; Lyt10 ; LYT10
Categories	Elisa
Function	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.
Specificity	Natural and recombinant Human Nuclear factor NF-kappa-B p100 subunit
Subcellular Location	Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor.
Detection Range	0.312-20ng/mL
Entryname	NFKB2_HUMAN
Method Type	Sandwich
Platform	PF00023
Protein Name	Nuclear factor NF-kappa-B p100 subunit
Sensitivity	0.12ng/mL
Sequence	50: MESCYNPGLD ; GIIEYDDFKL ; NSSIVEPKEP ; APETADGPYL ; VIVEQPKQRG ; 100: FRFRYGCEGP ; SHGGLPGASS ; EKGRKTYPTV ; KICNYEGPAK ; IEVDLVTHSD ; 150: PPRAHAHSLV ; GKQCSELGIC ; AVSVGPKDMT ; AQFNNLGVLH ; VTKKNMMGTM ; 200: IQKLQRQRLR ; SRPQGLTEAE ; QRELEQEAKE ; LKKVMDLSIV ; RLRFSAFLRA ; 250: SDGSFSLPLK ; PVISQPIHDS ; KSPGASNLKI ; SRMDKTAGSV ; RGGDEVYLLC ; 300: DKVQKDDIEV ; RFYEDDENGW ; QAFGDFSPTD ; VHKQYAIVFR ; TPPYHKMKIE ; 350: RPVTVFLQLK ; RKRGGDVSDS ; KQFTYYPLVE ; DKEEVQRKRR ; KALPTFSQPF ; 400: GGGSHMGGGS ; GGAAGGYGGA ; GGGGSLGFFP ; SSLAYSPYQS ; GAGPMGCYPG ; 450: GGGGAQMAAT ; VPSRDSGEEA ; AEPSAPSRTP ; QCEPQAPEML ; QRAREYNARL ; 500: FGLAQRSARA ; LLDYGVTADA ; RALLAGQRHL ; LTAQDENGDT ; PLHLAIIHGQ ; 550: TSVIEQIVYV ; IHHAQDLGVV ; NLTNHLHQTP ; LHLAVITGQT ; SVVSFLLRVG ; 600: ADPALLDRHG ; DSAMHLALRA ; GAGAPELLRA ; LLQSGAPAVP ; QLLHMPDFEG ; 650: LYPVHLAVRA ; RSPECLDLLV ; DSGAEVEATE ; RQGGRTALHL ; ATEMEELGLV ; 700: THLVTKLRAN ; VNARTFAGNT ; PLHLAAGLGY ; PTLTRLLLKA ; GADIHAENEE ; 750: PLCPLPSPPT ; SDSDSDSEGP ; EKDTRSSFRG ; HTPLDLTCST ; KVKTLLLNAA ; 800: QNTMEPPLTP ; PSPAGPGLSL ; GDTALQNLEQ ; LLDGPEAQGS ; WAELAERLGL ; 850: RSLVDTYRQT ; TSPSGSLLRS ; YELAGGDLAG ; LLEALSDMGL ; EEGVRLLRGP ; 900:
Sequence Length	900
String	Q00653
Sub Unit	Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.

Uniprot	Q00653
Gene Name	NFKB2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4791
Unigene	Hs.73090

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808139	E9393h	96T	$736		Add to Cart

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