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Home / Assay Kits / ELISA Kits

ELISA Kit for Human NAD-dependent deacetylase sirtuin-1

SKU : BHE13810272

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3949h
Alternative Names	SIR2-like protein 1 ; hSIR2 ; SIR2L1 ; Regulatory protein SIR2 homolog 1
Categories	Elisa
Function	NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Deacetylates 'Lys-266' of SUV39H1, leading to its activation. Deacetylates 'Lys-26' of HIST1H1E. Involved in HES1- and HEY2-mediated transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal muscle cell differentiation. Deacetylates 'Lys-16' of histone H4 (in vitro). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Deacetylates H2A. In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. Deacetylates APEX1 at 'Lys-6' and 'Lys-7'. Stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1.
Specificity	Natural and recombinant Human NAD-dependent deacetylase sirtuin-1
Subcellular Location	Nucleus PML body Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane.
Detection Range	78-5000pg/mL
Entryname	SIRT1_HUMAN
Method Type	Sandwich
Platform	PF02146
Protein Name	NAD-dependent deacetylase sirtuin-1
Sensitivity	32pg/mL
Sequence	50: MADEAALALQ ; PGGSPSAAGA ; DREAASSPAG ; EPLRKRPRRD ; GPGLERSPGE ; 100: PGGAAPEREV ; PAAARGCPGA ; AAAALWREAE ; AEAAAAGGEQ ; EAQATAAAGE ; 150: GDNGPGLQGP ; SREPPLADNL ; YDEDDDDEGE ; EEEEAAAAAI ; GYRDNLLFGD ; 200: EIITNGFHSC ; ESDEEDRASH ; ASSSDWTPRP ; RIGPYTFVQQ ; HLMIGTDPRT ; 250: ILKDLLPETI ; PPPELDDMTL ; WQIVINILSE ; PPKRKKRKDI ; NTIEDAVKLL ; 300: QECKKIIVLT ; GAGVSVSCGI ; PDFRSRDGIY ; ARLAVDFPDL ; PDPQAMFDIE ; 350: YFRKDPRPFF ; KFAKEIYPGQ ; FQPSLCHKFI ; ALSDKEGKLL ; RNYTQNIDTL ; 400: EQVAGIQRII ; QCHGSFATAS ; CLICKYKVDC ; EAVRGDIFNQ ; VVPRCPRCPA ; 450: DEPLAIMKPE ; IVFFGENLPE ; QFHRAMKYDK ; DEVDLLIVIG ; SSLKVRPVAL ; 500: IPSSIPHEVP ; QILINREPLP ; HLHFDVELLG ; DCDVIINELC ; HRLGGEYAKL ; 550: CCNPVKLSEI ; TEKPPRTQKE ; LAYLSELPPT ; PLHVSEDSSS ; PERTSPPDSS ; 600: VIVTLLDQAA ; KSNDDLDVSE ; SKGCMEEKPQ ; EVQTSRNVES ; IAEQMENPDL ; 650: KNVGSSTGEK ; NERTSVAGTV ; RKCWPNRVAK ; EQISRRLDGN ; QYLFLPPNRY ; 700: IFHGAEVYSD ; SEDDVLSSSS ; CGSNSDSGTC ; QSPSLEEPME ; DESEIEEFYN ; 747: GLEDEPDVPE ; RAGGAGFGTD ; GDDQEAINEA ; ISVKQEVTDM ; NYPSNKS
Sequence Length	747
String	Q96EB6
Sub Unit	Interacts with TAF1B. Found in a complex with PCAF and MYOD1 (By similarity). Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Interacts with MLLT7/FOXO4, HES1, HEY2, p53/TP53 and PML. Interacts with RPS19BP1/AROS. Interacts with KIAA1967/DBC1 (via N-terminus). Interacts with APEX1; the interaction is promoted in the context of genotoxic stress. Interacts with FOXO1 and this interaction requires the presence of KRIT1 (By similarity). Interacts with STK4/MST1.

Uniprot	Q96EB6
Gene Name	SIRT1
Kegg	hsa:23411
Unigene	Hs.369779

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810272	E3949h	96T	$736		Add to Cart

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