Class E basic helix-loop-helix protein 39 ; bHLHe39 ; Proto-oncogene c-Myc ; Transcription factor p64 ; BHLHE39
Categories
Elisa
Function
Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
Specificity
Natural and recombinant Human Myc proto-oncogene protein
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2.