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ELISA Kit for Human Microtubule-associated protein tau

SKU : BHE13811126

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1983h
Alternative Names	Neurofibrillary tangle protein ; Paired helical filament-tau ; PHF-tau ; MAPTL ; MTBT1 ; TAU
Categories	Elisa
Function	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Specificity	Natural and recombinant Human Microtubule-associated protein tau
Subcellular Location	Cytoplasm cytosol Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Cell projection axon Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Detection Range	7.8-500pg/mL
Entryname	TAU_HUMAN
Method Type	Sandwich
Platform	PF00418
Protein Name	Microtubule-associated protein tau
Sensitivity	3.5pg/mL
Sequence	50: MAEPRQEFEV ; MEDHAGTYGL ; GDRKDQGGYT ; MHQDQEGDTD ; AGLKESPLQT ; 100: PTEDGSEEPG ; SETSDAKSTP ; TAEDVTAPLV ; DEGAPGKQAA ; AQPHTEIPEG ; 150: TTAEEAGIGD ; TPSLEDEAAG ; HVTQEPESGK ; VVQEGFLREP ; GPPGLSHQLM ; 200: SGMPGAPLLP ; EGPREATRQP ; SGTGPEDTEG ; GRHAPELLKH ; QLLGDLHQEG ; 250: PPLKGAGGKE ; RPGSKEEVDE ; DRDVDESSPQ ; DSPPSKASPA ; QDGRPPQTAA ; 300: REATSIPGFP ; AEGAIPLPVD ; FLSKVSTEIP ; ASEPDGPSVG ; RAKGQDAPLE ; 350: FTFHVEITPN ; VQKEQAHSEE ; HLGRAAFPGA ; PGEGPEARGP ; SLGEDTKEAD ; 400: LPEPSEKQPA ; AAPRGKPVSR ; VPQLKARMVS ; KSKDGTGSDD ; KKAKTSTRSS ; 450: AKTLKNRPCL ; SPKHPTPGSS ; DPLIQPSSPA ; VCPEPPSSPK ; YVSSVTSRTG ; 500: SSGAKEMKLK ; GADGKTKIAT ; PRGAAPPGQK ; GQANATRIPA ; KTPPAPKTPP ; 550: SSGEPPKSGD ; RSGYSSPGSP ; GTPGSRSRTP ; SLPTPPTREP ; KKVAVVRTPP ; 600: KSPSSAKSRL ; QTAPVPMPDL ; KNVKSKIGST ; ENLKHQPGGG ; KVQIINKKLD ; 650: LSNVQSKCGS ; KDNIKHVPGG ; GSVQIVYKPV ; DLSKVTSKCG ; SLGNIHHKPG ; 700: GGQVEVKSEK ; LDFKDRVQSK ; IGSLDNITHV ; PGGGNKKIET ; HKLTFRENAK ; 750: AKTDHGAEIV ; YKSPVVSGDT ; SPRHLSNVSS ; TGSIDMVDSP ; QLATLADEVS ; 758: ASLAKQGL
Sequence Length	758
String	P10636
Sub Unit	Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with SQSTM1 when polyubiquitinated. Interacts with FKBP4.

Uniprot	P10636
Gene Name	MAPT
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4137
Unigene	Hs.101174

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811126	E1983h	96T	$736		Add to Cart

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