Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.
Specificity
Natural and recombinant Human Methyl-CpG-binding protein 2
Subcellular Location
Nucleus Colocalized with methyl-CpG in the genome.