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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Membrane cofactor protein

SKU : BHE13806585

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1275h
Alternative Names	TLX ; Trophoblast leukocyte common antigen ; CD46 ; MCP ; MIC10
Categories	Elisa
Function	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Specificity	Natural and recombinant Human Membrane cofactor protein
Subcellular Location	Cytoplasmic vesicle secretory vesicle acrosome inner membrane Single-pass type I membrane protein Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.
Detection Range	31.2-2000pg/mL
Entryname	MCP_HUMAN
Method Type	Sandwich
Platform	PF00084
Protein Name	Membrane cofactor protein
Sensitivity	10pg/mL
Sequence	50: MEPPGRRECP ; FPSWRFPGLL ; LAAMVLLLYS ; FSDACEEPPT ; FEAMELIGKP ; 100: KPYYEIGERV ; DYKCKKGYFY ; IPPLATHTIC ; DRNHTWLPVS ; DDACYRETCP ; 150: YIRDPLNGQA ; VPANGTYEFG ; YQMHFICNEG ; YYLIGEEILY ; CELKGSVAIW ; 200: SGKPPICEKV ; LCTPPPKIKN ; GKHTFSEVEV ; FEYLDAVTYS ; CDPAPGPDPF ; 250: SLIGESTIYC ; GDNSVWSRAA ; PECKVVKCRF ; PVVENGKQIS ; GFGKKFYYKA ; 300: TVMFECDKGF ; YLDGSDTIVC ; DSNSTWDPPV ; PKCLKVLPPS ; STKPPALSHS ; 350: VSTSSTTKSP ; ASSASGPRPT ; YKPPVSNYPG ; YPKPEEGILD ; SLDVWVIAVI ; 392: VIAIVVGVAV ; ICVVPYRYLQ ; RRKKKGTYLT ; DETHREVKFT ; SL
Sequence Length	392
String	P15529
Sub Unit	Interacts with C3b and C4b. Binds to Measles virus H protein, to Human herpesvirus 6 GH protein and to human adenovirus B/D PIV/fiber protein, and acts as a receptor for these viruses. Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria, and may act as a receptor for these pathogenic bacteria.

Uniprot	P15529
Gene Name	CD46
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4179
Unigene	Hs.510402

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806585	E1275h	96T	$736		Add to Cart

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