Opa-interacting protein 4 ; OIP-4 ; Preferentially expressed antigen of melanoma ; MAPE ; OIP4
Categories
Elisa
Function
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Specificity
Natural and recombinant Human Melanoma antigen preferentially expressed in tumors
Subcellular Location
Nucleus Cell membrane
Detection Range
0.156-10ng/mL
Entryname
PRAME_HUMAN
Method Type
Sandwich
Protein Name
Melanoma antigen preferentially expressed in tumors
Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.